CONTROL OF PATTERN FORMATION IN DROSOPHILA

果蝇模式形成的控制

• 批准号: 2177075
• 负责人: Gerold A. Schubiger
• 金额: $ 21.99万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2177075
• 关键词: Drosophilidae; actins; bioperiodicity; cell cell interaction; cell cycle; cell differentiation; cell migration; cytoskeleton; developmental genetics; embryogenesis; gel electrophoresis; gene expression; genetic regulation; genetic transcription; histogenesis; karyotype; micromanipulator; microtubules; monoclonal antibody; nucleic acid probes; protein degradation; scintillation counter

The objective of this investigation is to analyze specific developmental events and their temporal and spatial coordination. We will study morphological changes in the earliest phases of a Drosophila embryo. We will determine the elements of the cytoskeleton which move the nuclei to specific positions at specific times. These earliest phases of development are maternally regulated and at a specific stage, the zygotic genomic activity regulates the continuation of embryogenesis. We have begun to study how the transformation from maternal to zygotic control occurs and have pre observations which indicates that the normal program of development is regulated by multiple and synchronized time measuring devices. We will identify these mechanisms and ultimately hope to characterize genes and their products which regulate these mechanisms. Upon activation of transcription the embryo gastrulates and after gastrulation movements the three germlayers, ectoderm, mesoderm and endoderm, are established. As a consequence of these movements, cells have new neighbors. We will determine whether interactions with these new neighbors are required for the differentiation of germlayer specific identities.

这项研究的目的是分析特定的发展 事件及其时空协调。 我们将研究 果蝇胚胎早期的形态变化。 我们 将决定细胞骨架的元素，这些元素将细胞核移动到 在特定时间的特定位置。 这些最早的发育阶段是由母体调节的， 在特定的阶段，合子基因组活性调节的延续 胚胎发生 我们已经开始研究如何从母性的转变 合子控制发生，并有预先观察表明， 正常的发展程序是由多个和同步的 时间测量装置 我们将确定这些机制， 我们希望能够鉴定出调控这些基因及其产物， 机制等 转录激活后，胚胎形成原肠胚， 原肠胚形成运动的三个胚层，外胚层，中胚层和 内胚层，建立。 由于这些运动，细胞 新邻居 我们将确定是否与这些新的互动 需要邻居来分化胚层特异性 身份