CONTROL OF PATTERN FORMATION IN DROSOPHILA

本次调查的目的是分析具体的发展情况 事件及其时间和空间协调。 我们将学习 果蝇胚胎最早阶段的形态变化。 我们 将确定将细胞核移动到的细胞骨架的元素 特定时间的特定位置。 这些最早的发育阶段是由母体调节的，并且处于一个 在特定阶段，合子基因组活性调节着 胚胎发生。 我们已经开始研究母性如何转变 合子控制发生并且预先观察表明 正常的发展程序是受多重且同步的调节的 时间测量装置。 我们将确定这些机制并最终 希望表征基因及其调节这些的产物 机制。 转录激活后，胚胎原肠胚形成 原肠胚形成运动的三个胚层：外胚层、中胚层和 内胚层，已建立。 由于这些运动，细胞 新邻居。 我们将确定是否与这些新的相互作用 胚层特异性的分化需要邻居 身份。

The objective of this investigation is to analyze specific developmental events and their temporal and spatial coordination. We will study morphological changes in the earliest phases of a Drosophila embryo. We will determine the elements of the cytoskeleton which move the nuclei to specific positions at specific times. These earliest phases of development are maternally regulated and at a specific stage, the zygotic genomic activity regulates the continuation of embryogenesis. We have begun to study how the transformation from maternal to zygotic control occurs and have pre observations which indicates that the normal program of development is regulated by multiple and synchronized time measuring devices. We will identify these mechanisms and ultimately hope to characterize genes and their products which regulate these mechanisms. Upon activation of transcription the embryo gastrulates and after gastrulation movements the three germlayers, ectoderm, mesoderm and endoderm, are established. As a consequence of these movements, cells have new neighbors. We will determine whether interactions with these new neighbors are required for the differentiation of germlayer specific identities.