CORE--INFORMATICS

拟议项目的信息学核心将设在耶鲁大学 医学信息学中心，由佩里·米勒博士指导。这个 Informatics Core将建立在现有项目的基础上，该项目已经 开发物理基因作图数据库，支持所有 参加耶鲁大学的生物实验室。信息学核心将 包括以下活动：1)共享数据库将 实施和维护供所有参与实验室使用。这个 数据库将包括生物试剂的实验室清单， 实验结果，以及基于这些结果的地图。中环 服务器将是一个Sybase关系数据库。实验室将进入 该数据库使用运行第四维度(4D)的Macintosh计算机 关系数据库包作为一个非常人性化的前端，访问 Sybase使用的是“4D SQL Server”，这是一个商业客户端-服务器包。2) 例如，用于地图汇编、分析和显示的软件工具将 在服务器系统、本地Macintoshes和 网络。3)该数据库还将作为项目管理工具。 4)信息学工作人员将与 耶鲁大学和AECOM的参与实验室开发和完善 数据库系统，并培训他们使用该系统。5)信息学 活动将与其他国家和地区协调 国际社会在许多方面的合作。6)信息学员工将 继续维护、修改和更新数据库结构 映射技术被开发出来，并且随着新类型的映射数据被 生成的数据需要合并到数据库中。7) 参与实验室之间的交流将通过以下方式进行 电子邮件，并将通过协调 将因使用共享数据库而产生的活动。

The Informatics Core of the proposed project will be based at the Yale Center for Medical Informatics, directed by Dr. Perry Miller. The Informatics Core will build on an existing project which is already developing physical gene mapping database support for all of the participating biological laboratories at Yale. The Informatics Core will include the following activities: 1) A shared database will be implemented and maintained for use by all participating laboratories. The database will include laboratory inventories of biologic reagents, experimental results, and maps based on those results. The central server will be a Sybase relational database. Laboratories will access this database using Macintosh computers running the 4th-Dimension (4D) relational database package as a very user-friendly front end, accessing Sybase using "4D SQL Server," a commercial client-server package. 2) Software tools, for example for map assembly, analysis, and display, will run on the server system, on the local Macintoshes, and elsewhere on the network. 3) The database will also serve as a project management tool. 4) Informatics staff will work closely with the staff of the participating laboratories at Yale and at AECOM to develop and refine the database system, and to train them in its use. 5) The informatics activities will be coordinated with the rest of the national and international community in a number of ways. 6) Informatics staff will continue to maintain, modify, and update the database structure as new mapping techniques are developed, and as new types of mapping data are generated that need to be incorporated into the database. 7) Communication between the participating laboratories will be via electronic mail, and will be further enhanced by the coordination of activities that will result from use of the shared database.