Planning a Biomedical Computing Center of Excellence

规划卓越的生物医学计算中心

• 批准号: 6554023
• 负责人: Perry L. Miller
• 金额: $ 12.74万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6554023
• 关键词: computer center; computer system design /evaluation; education; education evaluation /planning; molecular biology information system

This application proposes a three-year project o plan for, and builds towards, a Biomedical Computing Center of Excellence at Yale. The overall theme of the Center will be: "Harnessing Advanced Computing Technologies for Biomedicine." The Center will provide a focus for highly collaborative research and training involving many academic units and research support units within Yale University as a whole. The initial focus will be on four research themes: 1) heterogeneous biomedical database design, b) multilevel approaches to facilitate interoperation among biological databases and software tools, c) integrative genomic database analysis, and d) high performance distributed biocomputing. These themes each build upon particular research strengths at Yale. The proposed activities including the following. 1. A central component of the proposal will involve planning for the establishment of the Center of Excellence. 2. A set of ongoing activities will promote interaction and collaboration among the academic units participating in the Center. 3. A Biomedical Computing Education Committee will plan for a full spectrum of educational activities. 4. Three pilot projects will be carried out: a) developing a flexible pilot EAV/CR database for describing heterogeneous microarray expression experiments, b) integrative data mining to relate protein characteristics to gene expression patterns, and c) computational and statistical analysis of gene expression as a dynamical system using high performance computing techniques. Although the pilot projects will focus on different computational research themes, they all focus on the challenges posed by the analysis of experimental microarray data. 5. A Biomedical Computing Core will support the activities of the three pilot projects.

本申请提出了一个为期三年的项目计划，并建立了一个卓越的耶鲁大学生物医学计算中心。该中心的总体主题将是：“利用先进的计算技术用于生物医学。“该中心将提供一个高度合作的研究和培训的重点，涉及许多学术单位和研究支持单位在耶鲁大学作为一个整体。最初的重点将是四个研究主题：1）异构生物医学数据库的设计，B）多层次的方法，以促进生物数据库和软件工具之间的互操作，c）综合基因组数据库分析，和d）高性能分布式生物计算。这些主题都建立在耶鲁大学特定的研究优势之上。拟议的活动包括以下内容。1.该提案的一个核心组成部分将涉及规划建立英才中心。2.一系列正在进行的活动将促进参与该中心的学术单位之间的互动与合作。3.一个生物医学计算教育委员会将计划一个全方位的教育活动。4.将开展三个试点项目：a）开发一个灵活的试点EAV/CR数据库，用于描述异质性微阵列表达实验，B）综合数据挖掘，将蛋白质特征与基因表达模式联系起来，以及c）使用高性能计算技术对作为动态系统的基因表达进行计算和统计分析。虽然试点项目将侧重于不同的计算研究主题，但它们都侧重于实验微阵列数据分析所带来的挑战。5.生物医学计算核心将支持三个试点项目的活动。