Shared Resources-Biomedical Informatics

共享资源-生物医学信息学

• 批准号: 7513326
• 负责人: Perry L. Miller
• 金额: $ 12.75万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-09 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513326
• 关键词: Bite; Cancer Center; Cancer Genetics Network; Clinical Informatics; Clinical Research; Clinical Trials; Clinical Trials Database; Collaborations; Confidentiality; DNA Microarray Chip; DNA Microarray format; Data; Data Analyses; Databases; Development; Funding; Genomics; Goals; Image; Informatics; Information Systems; Internet; Malignant Neoplasms; Medical Informatics; Medical center; National Cancer Institute; National Center for Research Resources; Numbers; Pathology; Peer Review; Proteomics; Registries; Research; Research Infrastructure; Research Personnel; Resource Sharing; Secure; Security; Services; Software Tools; System; Time; Tissue Microarray; Vendor; Work; base; biomedical informatics; cancer Biomedical Informatics Grid; member; programs; research study; tool; tumor

The Biomedical Informatics Shared Resource builds upon a longstanding collaboration among the Yale Center for Medical Informatics (YCMI), the YCC Clinical Research Service (CRS), and the Yale Department of Pathology Informatics Group. The Shared Resource was inaugurated in 1996 with the initial goal of developing a multi-disciplinary database to collect, store, curate, and help analyze data .for clinical trials and clinical research studies, a system now called Trial/DB. Over the past decade, the activities of the Shared Resource have significantly broadened. Trial/DB is now robustly operational and is being used for all YCC investigator initiated trials, and is continuing to be augmented and refined to meet the needs of YCC researchers. The TrialTracker system was built to track administrative informatics about trials, and is now used for all YCC trials. One major current project is developing a Cancer Data Repository (CaDR) building on the Yale Tumor Registry system. The development of the CaDR is a step toward developing a much broader institutional clinical data repository at Yale, using cancer as a pilot domain. Another initiative, in support of YCC bioscience, involves maintaining and refining two databases and related software tools, Cruella (for tissue array research) and GeneCube (for DMA microarray research). The Shared Resource is also involved in a number of activities related to the national caBIG initiative. Additional activities include 1) incrementally integrating Trial/DB, and ultimately the CaDR, with other information systems used by the YCC, and 2) coordinating YCC's activities with data-intensive genomic/proteomic informatics and clinical imaging infrastructure being developed at Yale. Overall usage of this facility by Cancer Center members is 94.6% (88.8% Peer-reviewed). The Shared Resource is utilized by 17 YCC users, based in 7 of the 8 YCC programs.

生物医学信息学共享资源建立在耶鲁大学中心 医学信息学（YCMI），YCC临床研究服务（CRS）和耶鲁大学医学系 病理学信息组。共享资源于1996年成立，最初的目标是开发 一个多学科数据库，用于收集、存储、管理和帮助分析数据。 一个名为Trial/DB的系统。在过去的十年里，共享资源 已经显著扩大了。 Trial/DB现已稳健运行，并用于所有YCC研究者发起的试验， 继续扩大和完善，以满足YCC研究人员的需求。 TrialTracker系统的建立是为了跟踪有关试验的行政信息，现在用于所有 YCC试验。 目前的一个主要项目是开发一个基于耶鲁肿瘤的癌症数据库（CaDR）。 登记制度。CaDR的发展是朝着发展一个更广泛的机构迈出的一步。 耶鲁大学的临床数据库，使用癌症作为试点领域。 另一项支持YCC生物科学的举措涉及维护和完善两个数据库和相关的 软件工具，Cruella（用于组织阵列研究）和GeneCube（用于DMA微阵列研究）。 共享资源还参与了一些与国家caBIG倡议有关的活动。 其他活动包括：1）逐步集成Trial/DB，最终集成CaDR， YCC使用的信息系统，以及2）协调YCC的活动与数据密集型 基因组/蛋白质组信息学和临床成像基础设施正在耶鲁大学开发。 癌症中心成员对该设施的总体使用率为94.6%（88.8%同行评审）。共享 资源被17个YCC用户使用，基于8个YCC方案中的7个。