TOOLS TO SUPPORT COMPUTER BASED CLINICAL GUIDELINES

描述（改编自申请人摘要）： 拟议的研究将建立，完善，并在操作使用中测试，一套 软件工具，旨在帮助支持，维护和迭代 随着时间的推移，重新验证基于计算机的临床指南。 的 该项目将侧重于儿童免疫领域，并将建立 IMM/Serve是一个儿童免疫预测计划， 输入儿童的免疫史，并提出建议， 哪些疫苗应该接种，哪些疫苗应该接种。 修改和验证这样一个程序所需的努力， 场随时间演变是一项具有挑战性的任务。 将极其 重要的是要有一套强大的工具来协助这一进程。 部分 其中某些工具的原型已经存在。 1. 该项目将改进和扩大基于计算机的免疫工具 知识维护。 这些工具将包括： 它自动生成基于规则的逻辑， IMM/Serve的知识的一部分（“内核”），以及B）IMM/Test，程序 它自动生成一组测试用例来帮助测试内核 逻辑 该项目还将制定一套有组织的战略， 免疫测试用例生成，并在 IMM/Test的改进版本。 2. 该项目将建立一个支持免疫知识的网站 上维护 3. 该项目将保留所有修改的详细记录， 知识的定制，并将代表所有的变化， 使用标准化格式的知识，如GLIF，指南 正在开发的交换格式，作为交换准则的标准 在站点之间。 4. 该项目将把IMM/Serve连接到一个数据库， IMM/Serve对一组案例的分析，这样得到的包就可以 用作执行合规性评估的工具。 5. 将进行一系列评估研究，以帮助评估 工具的有效性，并帮助改善其功能。

DESCRIPTION (Adapted from the applicant's abstract): The proposed research will build, refine, and test in operational use, a set of software tools designed to help support, maintain, and iteratively revalidate computer-based clinical guidelines as they evolve over time. The project will focus on the domain of childhood immunization, and will build upon IMM/Serve, a childhood immunization forecasting program that takes as input a child's immunization history, and produces recommendations as to which vaccinations are due and which vaccinations should be scheduled next. The effort required to modify and validate such a program as the clinical field evolves over time is a challenging task. It will be extremely important to have a robust set of tools to assist in this process. Partial prototype versions of certain of these tools already exist. 1. The project will refine and extend computer-based tools for immunization knowledge maintenance. These tools will include: a) IMM/Def, a program which automatically generates the rule-based logic for the most complex portion ("kernel") of IMM/Serve's knowledge, and b) IMM/Test, a program which automatically generates a set of test cases to help test the kernel logic. The project will also develop an organized set of strategies for immunization test case generation, and implement those strategies in the refined version of IMM/Test. 2. The project will build a Web site to support immunization knowledge maintenance. 3. The project will keep a detailed record of all modifications and customization of the knowledge, and will represent all the variations of the knowledge using a standardized format such as GLIF, the Guideline Interchange Format being developed as a standard for exchanging guidelines between sites. 4. The project will link IMM/Serve to a database designed to hold IMM/Serve's analysis of a set of cases, so that the resulting package can be used as a tool to perform compliance assessment. 5. A set of evaluation studies will be carried out to help assess the efficacy of the tools and to help improve their functionality.