CORE--INFORMATICS

拟议项目的信息学核心将设在耶鲁大学 医学信息学中心，由佩里米勒博士指导。 的 信息学核心将建立在一个现有的项目， 开发物理基因图谱数据库支持所有的 参与耶鲁大学的生物实验室。 信息学核心将 包括以下活动：1）共享数据库将 实施和维护，供所有参与实验室使用。的 数据库将包括生物试剂的实验室库存， 实验结果和基于这些结果的地图。 中央 服务器将是一个关系型数据库。 实验室将访问 该数据库使用运行第四维（4D）的Macintosh计算机 关系数据库包，作为一个非常人性化的前端，访问 使用“4D SQL Server”，一个商业客户端-服务器包。 （二） 用于地图组装、分析和显示等的软件工具将 在服务器系统上、在本地Macintosh上以及在 网络 3)该数据库还将作为项目管理工具。 4)信息学工作人员将与联合国工作人员密切合作， 参与实验室在耶鲁大学和AECOM开发和完善 数据库系统，并训练他们使用它。 5)信息学 活动将与全国其他地区协调， 国际社会以多种方式。 6)信息工作人员将 继续维护、修改和更新数据库结构， 开发了映射技术，并且随着新类型的映射数据被 生成的数据需要纳入数据库。 第七章） 参与实验室之间的通信将通过 电子邮件，并将通过协调 使用共享数据库将产生的活动。

The Informatics Core of the proposed project will be based at the Yale Center for Medical Informatics, directed by Dr. Perry Miller. The Informatics Core will build on an existing project which is already developing physical gene mapping database support for all of the participating biological laboratories at Yale. The Informatics Core will include the following activities: 1) A shared database will be implemented and maintained for use by all participating laboratories. The database will include laboratory inventories of biologic reagents, experimental results, and maps based on those results. The central server will be a Sybase relational database. Laboratories will access this database using Macintosh computers running the 4th-Dimension (4D) relational database package as a very user-friendly front end, accessing Sybase using "4D SQL Server," a commercial client-server package. 2) Software tools, for example for map assembly, analysis, and display, will run on the server system, on the local Macintoshes, and elsewhere on the network. 3) The database will also serve as a project management tool. 4) Informatics staff will work closely with the staff of the participating laboratories at Yale and at AECOM to develop and refine the database system, and to train them in its use. 5) The informatics activities will be coordinated with the rest of the national and international community in a number of ways. 6) Informatics staff will continue to maintain, modify, and update the database structure as new mapping techniques are developed, and as new types of mapping data are generated that need to be incorporated into the database. 7) Communication between the participating laboratories will be via electronic mail, and will be further enhanced by the coordination of activities that will result from use of the shared database.