Planning a Biomedical Computing Center of Excellence

这项申请提出了一个为期三年的计划，旨在建立耶鲁生物医学计算卓越中心。该中心的总体主题将是：“利用先进计算技术进行生物医学研究”。该中心将为高度协作的研究和培训提供重点，涉及耶鲁大学内部的许多学术单位和研究支持单位。最初的重点将集中在四个研究主题上：1)异质生物医学数据库设计，b)促进生物数据库和软件工具之间互操作的多层次方法，c)集成基因组数据库分析，d)高性能分布式生物计算。这些主题都建立在耶鲁大学独特的研究优势之上。拟开展的活动包括以下内容。1.该提案的一个核心部分将涉及规划建立英才中心。2.一系列正在进行的活动将促进参与中心的学术单位之间的互动和合作。3.生物医学计算教育委员会将规划全面的教育活动。4.将开展三个试点项目：a)开发一个灵活的试验性EAV/CR数据库，用于描述不同种类的微阵列表达实验；b)综合数据挖掘，将蛋白质特征与基因表达模式联系起来；c)利用高性能计算技术，将基因表达作为一个动态系统进行计算和统计分析。尽管试点项目将侧重于不同的计算研究主题，但它们都侧重于分析实验微阵列数据带来的挑战。5.生物医学计算核心将支持三个试点项目的活动。

This application proposes a three-year project o plan for, and builds towards, a Biomedical Computing Center of Excellence at Yale. The overall theme of the Center will be: "Harnessing Advanced Computing Technologies for Biomedicine." The Center will provide a focus for highly collaborative research and training involving many academic units and research support units within Yale University as a whole. The initial focus will be on four research themes: 1) heterogeneous biomedical database design, b) multilevel approaches to facilitate interoperation among biological databases and software tools, c) integrative genomic database analysis, and d) high performance distributed biocomputing. These themes each build upon particular research strengths at Yale. The proposed activities including the following. 1. A central component of the proposal will involve planning for the establishment of the Center of Excellence. 2. A set of ongoing activities will promote interaction and collaboration among the academic units participating in the Center. 3. A Biomedical Computing Education Committee will plan for a full spectrum of educational activities. 4. Three pilot projects will be carried out: a) developing a flexible pilot EAV/CR database for describing heterogeneous microarray expression experiments, b) integrative data mining to relate protein characteristics to gene expression patterns, and c) computational and statistical analysis of gene expression as a dynamical system using high performance computing techniques. Although the pilot projects will focus on different computational research themes, they all focus on the challenges posed by the analysis of experimental microarray data. 5. A Biomedical Computing Core will support the activities of the three pilot projects.