MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY

鼻腔和口腔控释系统的发展是 审查，特别强调化学和物理性质的 潜在的粘附性聚合物载体。新型共聚树脂 合成了含有羧基、羟基或离子的制剂 可与粘蛋白溶液、粘蛋白凝胶或粘膜相互作用的基团 提供相对永久的粘附性粘合剂。这些配方 可以以微粒的形式或以 薄薄的微盘。它们在水中或各种缓冲液中都可以膨胀。 解决办法。配方中使用的聚合物用 表面分析、电离度的测量和分析 交联性和溶胀度的关系。两个新颖的实验-- 心理技术被用来表征粘附性粘连 力量。鼻腔和口腔中的粘附性微粒 应用，使用含有粘蛋白凝胶或鼻腔的流动通道 粘液或有粘液的舌下组织。粒子从 粘液表面作为流体流动条件的函数进行了研究 (气体)从这个表面经过。对于微盘，拉伸测试 使用使候选生物粘附剂接触的过程 与粘液保持一段已知的时间，并通过 武力的运用。

The development of nasal and buccal controlled release systems is examined with special emphasis on the chemical and physical properties of the potentially mucoadhesive polymeric carriers. New copolymeric formulations were synthesized, containing carboxylic, hydroxylic or ionic groups which can interact with mucin solutions, mucin gels or mucosa to provide a relatively permanent mucoadhesive bond. These formulations could be prepared either in the form of microparticles or in the form of thin microdiscs. They were swellable in water or various buffered solutions. The polymers used in the formulations were characterized with surface analysis, measurement of their degree of ionization and analysis of the crosslinked properties and degree of swelling. Two novel experi- mental techniques are used to characterize the mucoadhesive bond strength. For muco-adhesive microparticles both in nasal and buccal applications, a flow channel is used containing a mucin gel or nasal mucus or sublingual tissue with mucus. The particle detachment from the mucus surface is studied as a function of flow conditions of the fluid (gas) passing over this surface. For microdiscs, a tensile testing process is used whereby the candidate bioadhesive is brought in contact with mucus for a known period of time and is further detached by application of force.