MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY

用于鼻腔和口腔给药的粘膜粘附聚合物

• 批准号: 3304419
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 10.42万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3304419
• 关键词: chemical bond; copolymer; crosslink; drug administration routes; drug delivery systems; drug interactions; hydropathy; mathematical model; mucosa; oral administration; oral mucosa; photoelectron spectrometry; polymers; solutions; water solution

The development of nasal and buccal controlled release systems is examined with special emphasis on the chemical and physical properties of the potentially mucoadhesive polymeric carriers. New copolymeric formulations were synthesized, containing carboxylic, hydroxylic or ionic groups which can interact with mucin solutions, mucin gels or mucosa to provide a relatively permanent mucoadhesive bond. These formulations could be prepared either in the form of microparticles or in the form of thin microdiscs. They were swellable in water or various buffered solutions. The polymers used in the formulations were characterized with surface analysis, measurement of their degree of ionization and analysis of the crosslinked properties and degree of swelling. Two novel experi- mental techniques are used to characterize the mucoadhesive bond strength. For muco-adhesive microparticles both in nasal and buccal applications, a flow channel is used containing a mucin gel or nasal mucus or sublingual tissue with mucus. The particle detachment from the mucus surface is studied as a function of flow conditions of the fluid (gas) passing over this surface. For microdiscs, a tensile testing process is used whereby the candidate bioadhesive is brought in contact with mucus for a known period of time and is further detached by application of force.

鼻及口腔控释系统的发展