MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY

用于鼻腔和口腔给药的粘膜粘附聚合物

基本信息

  • 批准号:
    3304419
  • 负责人:
  • 金额:
    $ 10.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1991
  • 资助国家:
    美国
  • 起止时间:
    1991-05-01 至 1994-04-30
  • 项目状态:
    已结题

项目摘要

The development of nasal and buccal controlled release systems is examined with special emphasis on the chemical and physical properties of the potentially mucoadhesive polymeric carriers. New copolymeric formulations were synthesized, containing carboxylic, hydroxylic or ionic groups which can interact with mucin solutions, mucin gels or mucosa to provide a relatively permanent mucoadhesive bond. These formulations could be prepared either in the form of microparticles or in the form of thin microdiscs. They were swellable in water or various buffered solutions. The polymers used in the formulations were characterized with surface analysis, measurement of their degree of ionization and analysis of the crosslinked properties and degree of swelling. Two novel experi- mental techniques are used to characterize the mucoadhesive bond strength. For muco-adhesive microparticles both in nasal and buccal applications, a flow channel is used containing a mucin gel or nasal mucus or sublingual tissue with mucus. The particle detachment from the mucus surface is studied as a function of flow conditions of the fluid (gas) passing over this surface. For microdiscs, a tensile testing process is used whereby the candidate bioadhesive is brought in contact with mucus for a known period of time and is further detached by application of force.
鼻及口腔控释系统的发展

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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NICHOLAS A PEPPAS其他文献

NICHOLAS A PEPPAS的其他文献

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{{ truncateString('NICHOLAS A PEPPAS', 18)}}的其他基金

Decoupling Hydrogel Stiffness and Diffusivity for Hematopoietic Stem Cell Culture and Differentiation
用于造血干细胞培养和分化的水凝胶刚度和扩散率的解耦
  • 批准号:
    10647478
  • 财政年份:
    2023
  • 资助金额:
    $ 10.42万
  • 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
  • 批准号:
    8339884
  • 财政年份:
    2011
  • 资助金额:
    $ 10.42万
  • 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
  • 批准号:
    8242598
  • 财政年份:
    2011
  • 资助金额:
    $ 10.42万
  • 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
  • 批准号:
    7797095
  • 财政年份:
    2009
  • 资助金额:
    $ 10.42万
  • 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
  • 批准号:
    8564198
  • 财政年份:
    2009
  • 资助金额:
    $ 10.42万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    6019316
  • 财政年份:
    1997
  • 资助金额:
    $ 10.42万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    2378414
  • 财政年份:
    1997
  • 资助金额:
    $ 10.42万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    2750155
  • 财政年份:
    1997
  • 资助金额:
    $ 10.42万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    3304418
  • 财政年份:
    1991
  • 资助金额:
    $ 10.42万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    2182934
  • 财政年份:
    1991
  • 资助金额:
    $ 10.42万
  • 项目类别:

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