MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY

用于鼻腔和口腔给药的粘膜粘附聚合物

• 批准号: 3304418
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 12.23万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3304418
• 关键词: chemical bond; copolymer; crosslink; drug administration routes; drug delivery systems; drug interactions; hydropathy; mathematical model; mucosa; oral administration; oral mucosa; photoelectron spectrometry; polymers; solutions; water solution

The development of nasal and buccal controlled release systems is examined with special emphasis on the chemical and physical properties of the potentially mucoadhesive polymeric carriers. New copolymeric formulations were synthesized, containing carboxylic, hydroxylic or ionic groups which can interact with mucin solutions, mucin gels or mucosa to provide a relatively permanent mucoadhesive bond. These formulations could be prepared either in the form of microparticles or in the form of thin microdiscs. They were swellable in water or various buffered solutions. The polymers used in the formulations were characterized with surface analysis, measurement of their degree of ionization and analysis of the crosslinked properties and degree of swelling. Two novel experi- mental techniques are used to characterize the mucoadhesive bond strength. For muco-adhesive microparticles both in nasal and buccal applications, a flow channel is used containing a mucin gel or nasal mucus or sublingual tissue with mucus. The particle detachment from the mucus surface is studied as a function of flow conditions of the fluid (gas) passing over this surface. For microdiscs, a tensile testing process is used whereby the candidate bioadhesive is brought in contact with mucus for a known period of time and is further detached by application of force.

鼻和颊控制释放系统的开发是 特别强调 潜在的粘粘性聚合物载体。 新的共聚 制剂合成，含羧酸，羟基或离子 可以与粘蛋白溶液，粘蛋白凝胶或粘膜相互作用的组 提供相对永久的粘附键。 这些配方 可以以微粒的形式或以 薄的微型散发。 它们在水中膨胀或各种缓冲 解决方案。 配方中使用的聚合物的表征 表面分析，测量其电离和分析程度 交联的特性和肿胀程度。 两个新颖的经验 - 心理技术用于表征粘附键 力量。 用于鼻和颊中的粘粘性微粒 应用，使用含有粘蛋白凝胶或鼻腔的流通道 带有粘液的粘液或舌下组织。 粒子脱离 研究粘液表面是流体流动条件的函数 （气）经过该表面。 对于微型盘，拉伸测试 使用过程，使候选生物粘附接触 与粘液一起在已知的时间段内，并被 施力。