PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS

PEG促进的粘膜粘附药物递送系统

• 批准号: 2750155
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 12.02万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750155
• 关键词: adhesions; bioenergetics; biomaterial evaluation; biotechnology; chemical chain length; chemical structure function; crosslink; diffusion; drug administration routes; drug delivery systems; gel; hydropathy; infrared spectrometry; interferometry; material; method development; mucins; mucus; pharmacokinetics; polyethylene glycols

DESCRIPTION: The investigators propose to develop and study the mucoadhesive behavior of hydrophilic polymer drug carriers that are modified by the addition of polyethylene glycols, as further described by their abstract: "The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. Bioadhesion is affected by the synergistic action of the biological environment, the properties of the polymeric controlled release device, and the presence of the drug itself. The delivery site and the device designed are dictated by the drug's molecular structure and its pharmacological behavior. Recent studies in our laboratory indicate that the mucoadhesive behavior of specific hydrophilic polymer structures used as carriers for drug delivery can be improved with the addition of poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be added to such structures by post-reaction grafting leading to PEG-tethered hydrogels. An additional method is by loading PEG into an already swollen hydrogel structure. In the present work we develop, characterize and evaluate new drug delivery systems containing PEG." "The fracture energy required to separate layers of hydrogel films in control with mucin is investigated to evaluate the impact of promoter chain diffusion on device/mucin adhesion and to obtain molecular information on the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a hydrogel and used as an adhesion promoter. The influence of PEG molecular weight and contact time on PEG diffusion across the hydrogel/mucin interface is investigated by using tensiometry and near-field FTIR microscopy. Fracture analysis provides details about the mechanism of muco-adhesion and conditions of improved adhesion. In our work, we concentrate also on the practical development of such PEG-tethered or PEG-promoted systems for transmucosal, buccal and nasal delivery systems."

描述：调查人员建议开发和研究 修饰的亲水聚合物药物载体的粘粘性行为 通过添加聚乙烯乙二醇，如其进一步描述 抽象的： “生物粘附控制药物输送的主要目标是定位 体内的递送装置，以增强药物吸收过程 特定地点的方式。 生物粘附受到协同作用的影响 生物环境，聚合物控制的特性 释放装置以及药物本身的存在。 送货网站和 该设备设计的是该药物的分子结构及其 药理行为。 我们实验室的最新研究表明 用作特定亲水性聚合物结构的粘膜粘附行为 增加药物的载体可以通过添加来改善 聚（乙二醇）（PEG）作为粘附启动子。 钉链可以是 通过术后接枝，添加到此类结构中 水凝胶。 另一种方法是将PEG加载到已经肿胀的 水凝胶结构。 在目前的工作中，我们制定，特征和 评估包含钉子的新药物输送系统。” “将水凝胶膜层分开所需的断裂能 研究用粘蛋白控制以评估启动子链的影响 对装置/粘蛋白粘附的扩散并获得有关分子信息 药物载体粘液粘附中的断裂能。 PEG已纳入 水凝胶并用作粘附启动子。 PEG分子的影响 PEG扩散在水凝胶/粘蛋白界面上的重量和接触时间 通过使用张力仪和近场FTIR显微镜研究。 断裂分析提供了有关粘附机制和 改善粘附的条件。 在我们的工作中，我们也集中于 这种钉螺旋或钉蛋白的系统的实际开发 跨肿瘤，颊和鼻输送系统。”