PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS

PEG促进的粘膜粘附药物递送系统

基本信息

  • 批准号:
    2750155
  • 负责人:
  • 金额:
    $ 12.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-08-01 至 2000-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: The investigators propose to develop and study the mucoadhesive behavior of hydrophilic polymer drug carriers that are modified by the addition of polyethylene glycols, as further described by their abstract: "The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. Bioadhesion is affected by the synergistic action of the biological environment, the properties of the polymeric controlled release device, and the presence of the drug itself. The delivery site and the device designed are dictated by the drug's molecular structure and its pharmacological behavior. Recent studies in our laboratory indicate that the mucoadhesive behavior of specific hydrophilic polymer structures used as carriers for drug delivery can be improved with the addition of poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be added to such structures by post-reaction grafting leading to PEG-tethered hydrogels. An additional method is by loading PEG into an already swollen hydrogel structure. In the present work we develop, characterize and evaluate new drug delivery systems containing PEG." "The fracture energy required to separate layers of hydrogel films in control with mucin is investigated to evaluate the impact of promoter chain diffusion on device/mucin adhesion and to obtain molecular information on the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a hydrogel and used as an adhesion promoter. The influence of PEG molecular weight and contact time on PEG diffusion across the hydrogel/mucin interface is investigated by using tensiometry and near-field FTIR microscopy. Fracture analysis provides details about the mechanism of muco-adhesion and conditions of improved adhesion. In our work, we concentrate also on the practical development of such PEG-tethered or PEG-promoted systems for transmucosal, buccal and nasal delivery systems."
描述:研究人员拟开发和研究

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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NICHOLAS A PEPPAS其他文献

NICHOLAS A PEPPAS的其他文献

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{{ truncateString('NICHOLAS A PEPPAS', 18)}}的其他基金

Decoupling Hydrogel Stiffness and Diffusivity for Hematopoietic Stem Cell Culture and Differentiation
用于造血干细胞培养和分化的水凝胶刚度和扩散率的解耦
  • 批准号:
    10647478
  • 财政年份:
    2023
  • 资助金额:
    $ 12.02万
  • 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
  • 批准号:
    8339884
  • 财政年份:
    2011
  • 资助金额:
    $ 12.02万
  • 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
  • 批准号:
    8242598
  • 财政年份:
    2011
  • 资助金额:
    $ 12.02万
  • 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
  • 批准号:
    7797095
  • 财政年份:
    2009
  • 资助金额:
    $ 12.02万
  • 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
  • 批准号:
    8564198
  • 财政年份:
    2009
  • 资助金额:
    $ 12.02万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    6019316
  • 财政年份:
    1997
  • 资助金额:
    $ 12.02万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    2378414
  • 财政年份:
    1997
  • 资助金额:
    $ 12.02万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    3304419
  • 财政年份:
    1991
  • 资助金额:
    $ 12.02万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    3304418
  • 财政年份:
    1991
  • 资助金额:
    $ 12.02万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    2182934
  • 财政年份:
    1991
  • 资助金额:
    $ 12.02万
  • 项目类别:

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