PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS

PEG促进的粘膜粘附药物递送系统

• 批准号: 2750155
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 12.02万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750155
• 关键词: adhesions; bioenergetics; biomaterial evaluation; biotechnology; chemical chain length; chemical structure function; crosslink; diffusion; drug administration routes; drug delivery systems; gel; hydropathy; infrared spectrometry; interferometry; material; method development; mucins; mucus; pharmacokinetics; polyethylene glycols

DESCRIPTION: The investigators propose to develop and study the mucoadhesive behavior of hydrophilic polymer drug carriers that are modified by the addition of polyethylene glycols, as further described by their abstract: "The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. Bioadhesion is affected by the synergistic action of the biological environment, the properties of the polymeric controlled release device, and the presence of the drug itself. The delivery site and the device designed are dictated by the drug's molecular structure and its pharmacological behavior. Recent studies in our laboratory indicate that the mucoadhesive behavior of specific hydrophilic polymer structures used as carriers for drug delivery can be improved with the addition of poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be added to such structures by post-reaction grafting leading to PEG-tethered hydrogels. An additional method is by loading PEG into an already swollen hydrogel structure. In the present work we develop, characterize and evaluate new drug delivery systems containing PEG." "The fracture energy required to separate layers of hydrogel films in control with mucin is investigated to evaluate the impact of promoter chain diffusion on device/mucin adhesion and to obtain molecular information on the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a hydrogel and used as an adhesion promoter. The influence of PEG molecular weight and contact time on PEG diffusion across the hydrogel/mucin interface is investigated by using tensiometry and near-field FTIR microscopy. Fracture analysis provides details about the mechanism of muco-adhesion and conditions of improved adhesion. In our work, we concentrate also on the practical development of such PEG-tethered or PEG-promoted systems for transmucosal, buccal and nasal delivery systems."

描述：调查人员建议开发和研究 改性亲水聚合物药物载体的粘附性 通过添加聚乙二醇，如其进一步描述的那样 摘要： “生物黏附控制给药的主要目标是将一种 体内的给药装置，以增强药物在体内的吸收过程 特定于站点的方式。生物粘附力受以下因素的协同作用的影响 对生物环境、聚合物的性能进行控制 释放装置，以及药物本身的存在。交货地点和 设计的设备是由药物的分子结构和它的 药理行为。我们实验室最近的研究表明 特殊亲水性聚合物结构的粘附性 药物输送载体可以通过添加 聚乙二醇(PEG)作为粘合促进剂。钉住链可以是 通过反应后接枝添加到这样的结构上，从而得到聚乙二醇系留 水凝胶。另一种方法是将聚乙二醇加载到已经肿胀的 水凝胶结构。在目前的工作中，我们开发、表征和 评估含有聚乙二醇组分的新型药物输送系统。“ “将水凝胶层分开所需的断裂能 用粘蛋白进行控制以评估启动子链的影响 在设备/粘蛋白粘连上的扩散并获得关于 药物载体黏附中的断裂能。Peg并入了一个 水凝胶，用作粘合促进剂。聚乙二醇单分子的影响 聚乙二醇水凝胶/粘蛋白界面扩散的重量和接触时间 用张力计和近场傅里叶变换红外显微镜对其进行了研究。 骨折分析提供了粘连和粘连机制的详细信息 改善附着力的条件。在我们的工作中，我们还专注于 这类聚乙二醇系留或聚乙二醇化系统的实际开发 经粘膜、口腔和鼻腔给药系统。