Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered

口服药效调节的生物物理机制研究

基本信息

项目摘要

Project 4 is dealing with various physical barriers that chemotherapeutical agent administered orally meets on its way to be systemically absorbed and to reach the target tumor tissue. These barriers include for example: changes in pH across the gastrointestinal (Gl) tract, enzymatic degradation, epithelial transport through different mechanisms. To study and tackle these barriers we will use our engineered polymeric carriers. This project is led by Dr. Nicholas Peppas using animal models of Dr. Fidler as described in Project 1. Dr. Nicholas Peppas is a Professor in the Departments of Chemical, Biomedical Engineering and Pharmaceutics and Fletcher S. Pratt Chair of Engineering at UTA. Dr. Peppas is a world leader in the fields of bionanotechnology and molecular recognition processes, nanodevices for controlled drug delivery, and intelligent biomaterials. Among other medical devices, he has developed, patented and/or commercialized intraocular lenses, materials for vocal cord restoration, nanodelivery systems for oral administration of insulin to type I diabetic patients, and systems for oral delivery of calcitonin for treatment of postmenopausal women suffering from osteoporosis. Dr. Peppas is a member of the National Academy of Engineering, a member of the Institute of Medicine of the National Academy of Sciences and the French Academy of Pharmacy.
项目4是处理口服给药的化疗剂在全身吸收和到达靶肿瘤组织的过程中遇到的各种物理障碍。这些屏障包括例如:胃肠道(GI)中pH的变化、酶降解、通过不同机制的上皮转运。为了研究和解决这些障碍,我们将使用我们的工程聚合物载体。该项目由Nicholas Peppas博士领导,使用Fidler博士的动物模型,如项目1所述。Nicholas Peppas博士是化学、生物医学工程和制药学系的教授,弗莱彻S。UTA的Pratt工程主席。Peppas博士是生物纳米技术和分子识别过程、受控药物输送纳米器件和智能生物材料领域的世界领导者。在其他医疗器械中,他开发了人工晶状体、声带修复材料、用于I型糖尿病患者口服胰岛素的纳米递送系统,以及用于治疗绝经后骨质疏松症的降钙素口服递送系统,并获得了专利和/或商业化。Peppas博士是美国国家工程院院士、美国国家科学院医学研究所院士和法国药学院院士。

项目成果

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NICHOLAS A PEPPAS其他文献

NICHOLAS A PEPPAS的其他文献

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{{ truncateString('NICHOLAS A PEPPAS', 18)}}的其他基金

Decoupling Hydrogel Stiffness and Diffusivity for Hematopoietic Stem Cell Culture and Differentiation
用于造血干细胞培养和分化的水凝胶刚度和扩散率的解耦
  • 批准号:
    10647478
  • 财政年份:
    2023
  • 资助金额:
    $ 22.24万
  • 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
  • 批准号:
    8339884
  • 财政年份:
    2011
  • 资助金额:
    $ 22.24万
  • 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
  • 批准号:
    8242598
  • 财政年份:
    2011
  • 资助金额:
    $ 22.24万
  • 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
  • 批准号:
    7797095
  • 财政年份:
    2009
  • 资助金额:
    $ 22.24万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    6019316
  • 财政年份:
    1997
  • 资助金额:
    $ 22.24万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    2378414
  • 财政年份:
    1997
  • 资助金额:
    $ 22.24万
  • 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
  • 批准号:
    2750155
  • 财政年份:
    1997
  • 资助金额:
    $ 22.24万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    3304419
  • 财政年份:
    1991
  • 资助金额:
    $ 22.24万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    3304418
  • 财政年份:
    1991
  • 资助金额:
    $ 22.24万
  • 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
  • 批准号:
    2182934
  • 财政年份:
    1991
  • 资助金额:
    $ 22.24万
  • 项目类别:

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