Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered

口服药效调节的生物物理机制研究

基本信息

批准号：
8564198
负责人：
NICHOLAS A PEPPAS
金额：
$ 22.24万
依托单位：
METHODIST HOSPITAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8564198
关键词：
Academy Animal Model Animals Biocompatible Materials Bioinformatics Biomedical Engineering Blood Circulation Calcitonin Cell Proliferation Cells Characteristics Chemicals Chitosan Collaborations Colorectal Cancer Colorectal Neoplasms Diffusion Disease Drug Delivery Systems Drug Kinetics Electrical Resistance Engineering Enhancers Environment Epithelial Epithelial Cells Evaluation Face Gastrointestinal tract structure Growth In Vitro Institute of Medicine (U.S.)Insulin Intestines Intraocular lens implant device Kinetics Label Legal patent Measurement Measures Medical Device Membrane Modeling Oral Oral Administration Osteoporosis Pharmaceutical Preparations Pharmacy (field)Pharmacy facility Physics Plasma Postmenopause Process Property Reaction Research Signal Transduction Staging Stimulus Structure System Testing Tight Junctions Toxic effect Tumor Tissue United States National Academy of Sciences Woman absorption bile salts carrier mediated transport chemical property chemotherapeutic agent design diabetic patient gastrointestinal gastrointestinal epithelium hydrophilicity in vivo intestinal epithelium ionization meetings member metastatic colorectal molecular recognition monolayer nanobiotechnology nanodevice nanoparticle pH gradient particle prevent professor research study response restoration tool transcytosis tumor type I diabetic vocal cord

项目摘要

Project 4 is dealing with various physical barriers that chemotherapeutical agent administered orally meets on its way to be systemically absorbed and to reach the target tumor tissue. These barriers include for example: changes in pH across the gastrointestinal (Gl) tract, enzymatic degradation, epithelial transport through different mechanisms. To study and tackle these barriers we will use our engineered polymeric carriers. This project is led by Dr. Nicholas Peppas using animal models of Dr. Fidler as described in Project 1. Dr. Nicholas Peppas is a Professor in the Departments of Chemical, Biomedical Engineering and Pharmaceutics and Fletcher S. Pratt Chair of Engineering at UTA. Dr. Peppas is a world leader in the fields of bionanotechnology and molecular recognition processes, nanodevices for controlled drug delivery, and intelligent biomaterials. Among other medical devices, he has developed, patented and/or commercialized intraocular lenses, materials for vocal cord restoration, nanodelivery systems for oral administration of insulin to type I diabetic patients, and systems for oral delivery of calcitonin for treatment of postmenopausal women suffering from osteoporosis. Dr. Peppas is a member of the National Academy of Engineering, a member of the Institute of Medicine of the National Academy of Sciences and the French Academy of Pharmacy.

项目4正在处理化学治疗剂在系统吸收并到达靶肿瘤组织的方式上口服遇到的各种物理障碍。这些障碍包括：跨胃肠道（GL）的pH变化，酶促降解，上皮运输通过不同的机制。为了研究和应对这些障碍，我们将使用我们的工程聚合物载体。该项目由尼古拉斯·帕帕斯（Nicholas Peppas）博士使用菲德勒（Fidler）博士的动物模型领导。 Peppas博士是BionAnotechnology and Molecular识别过程，用于受控药物输送的纳米电视和智能生物材料领域的世界领导者。在其他医疗设备中，他已经开发，获得专利和/或商业化的眼内镜头，声带恢复的材料，用于口服胰岛素以进行I型糖尿病患者的纳米传递系统以及用于治疗降钙素的系统，用于治疗患有骨质疏松症的绝经后妇女。 Peppas博士是美国国家工程学院的成员，是美国国家科学院医学研究所和法国药学院的成员。