PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
基本信息
- 批准号:2378414
- 负责人:
- 金额:$ 16.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-01 至 2000-07-31
- 项目状态:已结题
- 来源:
- 关键词:adhesions bioenergetics biomaterial evaluation biotechnology chemical chain length chemical structure function crosslink diffusion drug administration routes drug delivery systems gel hydropathy infrared spectrometry interferometry material method development mucins mucus pharmacokinetics polyethylene glycols
项目摘要
DESCRIPTION: The investigators propose to develop and study the
mucoadhesive behavior of hydrophilic polymer drug carriers that are modified
by the addition of polyethylene glycols, as further described by their
abstract:
"The primary goal of bioadhesive controlled drug delivery is to localize a
delivery device within the body to enhance the drug absorption process in a
site-specific manner. Bioadhesion is affected by the synergistic action of
the biological environment, the properties of the polymeric controlled
release device, and the presence of the drug itself. The delivery site and
the device designed are dictated by the drug's molecular structure and its
pharmacological behavior. Recent studies in our laboratory indicate that
the mucoadhesive behavior of specific hydrophilic polymer structures used as
carriers for drug delivery can be improved with the addition of
poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be
added to such structures by post-reaction grafting leading to PEG-tethered
hydrogels. An additional method is by loading PEG into an already swollen
hydrogel structure. In the present work we develop, characterize and
evaluate new drug delivery systems containing PEG."
"The fracture energy required to separate layers of hydrogel films in
control with mucin is investigated to evaluate the impact of promoter chain
diffusion on device/mucin adhesion and to obtain molecular information on
the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a
hydrogel and used as an adhesion promoter. The influence of PEG molecular
weight and contact time on PEG diffusion across the hydrogel/mucin interface
is investigated by using tensiometry and near-field FTIR microscopy.
Fracture analysis provides details about the mechanism of muco-adhesion and
conditions of improved adhesion. In our work, we concentrate also on the
practical development of such PEG-tethered or PEG-promoted systems for
transmucosal, buccal and nasal delivery systems."
描述:研究人员建议开发和研究
亲水性高分子药物载体修饰后的粘膜粘附行为
通过添加聚乙二醇,如其进一步描述的
抽象的:
“生物粘附控制药物输送的主要目标是局部化
体内的输送装置可增强药物的吸收过程
特定地点的方式。 生物粘附受以下物质的协同作用影响
生物环境、聚合物控制的特性
释放装置以及药物本身的存在。 交货地点和
设计的装置由药物的分子结构及其作用决定
药理行为。 我们实验室最近的研究表明
用作特定亲水性聚合物结构的粘膜粘附行为
药物输送载体可以通过添加来改进
聚乙二醇(PEG)作为粘合促进剂。 PEG链可以是
通过反应后接枝添加到此类结构中,从而形成 PEG 系链
水凝胶。 另一种方法是将 PEG 加载到已经膨胀的
水凝胶结构。 在目前的工作中,我们开发、描述和
评估含有 PEG 的新药物输送系统。”
“分离水凝胶薄膜层所需的断裂能
研究了粘蛋白的控制以评估启动子链的影响
装置/粘蛋白粘附上的扩散并获得分子信息
药物载体粘膜粘附的断裂能。 PEG 被掺入
水凝胶并用作粘合促进剂。 PEG分子的影响
重量和接触时间对 PEG 在水凝胶/粘蛋白界面扩散的影响
通过使用张力测定法和近场 FTIR 显微镜进行研究。
断裂分析提供了有关粘膜粘附机制的详细信息和
改善附着力的条件。 在我们的工作中,我们还专注于
此类 PEG 系链或 PEG 促进系统的实际开发
跨粘膜、口腔和鼻腔输送系统。”
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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NICHOLAS A PEPPAS其他文献
NICHOLAS A PEPPAS的其他文献
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{{ truncateString('NICHOLAS A PEPPAS', 18)}}的其他基金
Decoupling Hydrogel Stiffness and Diffusivity for Hematopoietic Stem Cell Culture and Differentiation
用于造血干细胞培养和分化的水凝胶刚度和扩散率的解耦
- 批准号:
10647478 - 财政年份:2023
- 资助金额:
$ 16.17万 - 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
- 批准号:
8339884 - 财政年份:2011
- 资助金额:
$ 16.17万 - 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
- 批准号:
8242598 - 财政年份:2011
- 资助金额:
$ 16.17万 - 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
- 批准号:
7797095 - 财政年份:2009
- 资助金额:
$ 16.17万 - 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
- 批准号:
8564198 - 财政年份:2009
- 资助金额:
$ 16.17万 - 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
- 批准号:
6019316 - 财政年份:1997
- 资助金额:
$ 16.17万 - 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
- 批准号:
2750155 - 财政年份:1997
- 资助金额:
$ 16.17万 - 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
- 批准号:
3304419 - 财政年份:1991
- 资助金额:
$ 16.17万 - 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
- 批准号:
3304418 - 财政年份:1991
- 资助金额:
$ 16.17万 - 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
- 批准号:
2182934 - 财政年份:1991
- 资助金额:
$ 16.17万 - 项目类别:
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