PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
基本信息
- 批准号:2378414
- 负责人:
- 金额:$ 16.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-01 至 2000-07-31
- 项目状态:已结题
- 来源:
- 关键词:adhesions bioenergetics biomaterial evaluation biotechnology chemical chain length chemical structure function crosslink diffusion drug administration routes drug delivery systems gel hydropathy infrared spectrometry interferometry material method development mucins mucus pharmacokinetics polyethylene glycols
项目摘要
DESCRIPTION: The investigators propose to develop and study the
mucoadhesive behavior of hydrophilic polymer drug carriers that are modified
by the addition of polyethylene glycols, as further described by their
abstract:
"The primary goal of bioadhesive controlled drug delivery is to localize a
delivery device within the body to enhance the drug absorption process in a
site-specific manner. Bioadhesion is affected by the synergistic action of
the biological environment, the properties of the polymeric controlled
release device, and the presence of the drug itself. The delivery site and
the device designed are dictated by the drug's molecular structure and its
pharmacological behavior. Recent studies in our laboratory indicate that
the mucoadhesive behavior of specific hydrophilic polymer structures used as
carriers for drug delivery can be improved with the addition of
poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be
added to such structures by post-reaction grafting leading to PEG-tethered
hydrogels. An additional method is by loading PEG into an already swollen
hydrogel structure. In the present work we develop, characterize and
evaluate new drug delivery systems containing PEG."
"The fracture energy required to separate layers of hydrogel films in
control with mucin is investigated to evaluate the impact of promoter chain
diffusion on device/mucin adhesion and to obtain molecular information on
the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a
hydrogel and used as an adhesion promoter. The influence of PEG molecular
weight and contact time on PEG diffusion across the hydrogel/mucin interface
is investigated by using tensiometry and near-field FTIR microscopy.
Fracture analysis provides details about the mechanism of muco-adhesion and
conditions of improved adhesion. In our work, we concentrate also on the
practical development of such PEG-tethered or PEG-promoted systems for
transmucosal, buccal and nasal delivery systems."
描述:研究人员建议开发和研究
亲水性聚合物药物载体的粘膜粘附行为
通过加入聚乙二醇,如通过它们的
摘要:
“生物粘附控制药物递送的主要目标是定位
在体内的递送装置,以增强药物吸收过程,
具体的方式。 生物粘附受以下因素的协同作用影响:
生物环境,聚合物的性能控制
释放装置和药物本身的存在。 交货地点和
这种装置的设计是由药物的分子结构及其
药理学行为 我们实验室最近的研究表明,
用作亲水性聚合物结构的特定亲水性聚合物结构的粘膜粘附行为
用于药物递送的载体可以通过加入
聚乙二醇(PEG)作为粘合促进剂。 PEG链可以是
通过反应后接枝添加到这样的结构中,导致PEG-栓系的
水凝胶 另一种方法是通过将PEG加载到已经溶胀的
水凝胶结构。 在目前的工作中,我们开发,表征和
评估含有PEG的新药物递送系统。"
“将水凝胶膜层分离所需的断裂能量
研究粘蛋白的控制以评估启动子链的影响
器械/粘蛋白粘附上的扩散,并获得以下分子信息
药物载体粘膜粘附中的断裂能。 PEG被引入到
水凝胶并用作粘合促进剂。 PEG分子量的影响
PEG扩散穿过水凝胶/粘蛋白界面的重量和接触时间
通过使用张力计和近场FTIR显微镜研究。
断裂分析提供了关于粘膜粘附机制的细节,
改善粘合力的条件。 在我们的工作中,
这种PEG栓系或PEG促进的系统的实际开发,
经粘膜、口腔和鼻递送系统。"
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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NICHOLAS A PEPPAS其他文献
NICHOLAS A PEPPAS的其他文献
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{{ truncateString('NICHOLAS A PEPPAS', 18)}}的其他基金
Decoupling Hydrogel Stiffness and Diffusivity for Hematopoietic Stem Cell Culture and Differentiation
用于造血干细胞培养和分化的水凝胶刚度和扩散率的解耦
- 批准号:
10647478 - 财政年份:2023
- 资助金额:
$ 16.17万 - 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
- 批准号:
8339884 - 财政年份:2011
- 资助金额:
$ 16.17万 - 项目类别:
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug Delivery
用于先进药物输送的热响应磁水凝胶纳米复合材料
- 批准号:
8242598 - 财政年份:2011
- 资助金额:
$ 16.17万 - 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
- 批准号:
7797095 - 财政年份:2009
- 资助金额:
$ 16.17万 - 项目类别:
Study of he Biophysical Mechanisms Regulating the Efficacy of Orally Administered
口服药效调节的生物物理机制研究
- 批准号:
8564198 - 财政年份:2009
- 资助金额:
$ 16.17万 - 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
- 批准号:
6019316 - 财政年份:1997
- 资助金额:
$ 16.17万 - 项目类别:
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
PEG促进的粘膜粘附药物递送系统
- 批准号:
2750155 - 财政年份:1997
- 资助金额:
$ 16.17万 - 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
- 批准号:
3304419 - 财政年份:1991
- 资助金额:
$ 16.17万 - 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
- 批准号:
3304418 - 财政年份:1991
- 资助金额:
$ 16.17万 - 项目类别:
MUCOADHESIVE POLYMERS FOR NASAL AND BUCCAL DRUG DELIVERY
用于鼻腔和口腔给药的粘膜粘附聚合物
- 批准号:
2182934 - 财政年份:1991
- 资助金额:
$ 16.17万 - 项目类别:
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