PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS

PEG促进的粘膜粘附药物递送系统

• 批准号: 2378414
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 16.17万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2378414
• 关键词: adhesions; bioenergetics; biomaterial evaluation; biotechnology; chemical chain length; chemical structure function; crosslink; diffusion; drug administration routes; drug delivery systems; gel; hydropathy; infrared spectrometry; interferometry; material; method development; mucins; mucus; pharmacokinetics; polyethylene glycols

DESCRIPTION: The investigators propose to develop and study the mucoadhesive behavior of hydrophilic polymer drug carriers that are modified by the addition of polyethylene glycols, as further described by their abstract: "The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. Bioadhesion is affected by the synergistic action of the biological environment, the properties of the polymeric controlled release device, and the presence of the drug itself. The delivery site and the device designed are dictated by the drug's molecular structure and its pharmacological behavior. Recent studies in our laboratory indicate that the mucoadhesive behavior of specific hydrophilic polymer structures used as carriers for drug delivery can be improved with the addition of poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be added to such structures by post-reaction grafting leading to PEG-tethered hydrogels. An additional method is by loading PEG into an already swollen hydrogel structure. In the present work we develop, characterize and evaluate new drug delivery systems containing PEG." "The fracture energy required to separate layers of hydrogel films in control with mucin is investigated to evaluate the impact of promoter chain diffusion on device/mucin adhesion and to obtain molecular information on the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a hydrogel and used as an adhesion promoter. The influence of PEG molecular weight and contact time on PEG diffusion across the hydrogel/mucin interface is investigated by using tensiometry and near-field FTIR microscopy. Fracture analysis provides details about the mechanism of muco-adhesion and conditions of improved adhesion. In our work, we concentrate also on the practical development of such PEG-tethered or PEG-promoted systems for transmucosal, buccal and nasal delivery systems."

描述：研究人员建议开发和研究 亲水性高分子药物载体修饰后的粘膜粘附行为 通过添加聚乙二醇，如其进一步描述的 抽象的： “生物粘附控制药物输送的主要目标是局部化 体内的输送装置可增强药物的吸收过程 特定地点的方式。 生物粘附受以下物质的协同作用影响 生物环境、聚合物控制的特性 释放装置以及药物本身的存在。 交货地点和 设计的装置由药物的分子结构及其作用决定 药理行为。 我们实验室最近的研究表明 用作特定亲水性聚合物结构的粘膜粘附行为 药物输送载体可以通过添加来改进 聚乙二醇（PEG）作为粘合促进剂。 PEG链可以是 通过反应后接枝添加到此类结构中，从而形成 PEG 系链 水凝胶。 另一种方法是将 PEG 加载到已经膨胀的 水凝胶结构。 在目前的工作中，我们开发、描述和 评估含有 PEG 的新药物输送系统。” “分离水凝胶薄膜层所需的断裂能 研究了粘蛋白的控制以评估启动子链的影响 装置/粘蛋白粘附上的扩散并获得分子信息 药物载体粘膜粘附的断裂能。 PEG 被掺入 水凝胶并用作粘合促进剂。 PEG分子的影响 重量和接触时间对 PEG 在水凝胶/粘蛋白界面扩散的影响 通过使用张力测定法和近场 FTIR 显微镜进行研究。 断裂分析提供了有关粘膜粘附机制的详细信息和 改善附着力的条件。 在我们的工作中，我们还专注于 此类 PEG 系链或 PEG 促进系统的实际开发 跨粘膜、口腔和鼻腔输送系统。”