PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS

PEG促进的粘膜粘附药物递送系统

• 批准号: 2378414
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 16.17万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2378414
• 关键词: adhesions; bioenergetics; biomaterial evaluation; biotechnology; chemical chain length; chemical structure function; crosslink; diffusion; drug administration routes; drug delivery systems; gel; hydropathy; infrared spectrometry; interferometry; material; method development; mucins; mucus; pharmacokinetics; polyethylene glycols

DESCRIPTION: The investigators propose to develop and study the mucoadhesive behavior of hydrophilic polymer drug carriers that are modified by the addition of polyethylene glycols, as further described by their abstract: "The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. Bioadhesion is affected by the synergistic action of the biological environment, the properties of the polymeric controlled release device, and the presence of the drug itself. The delivery site and the device designed are dictated by the drug's molecular structure and its pharmacological behavior. Recent studies in our laboratory indicate that the mucoadhesive behavior of specific hydrophilic polymer structures used as carriers for drug delivery can be improved with the addition of poly(ethylene glycol) (PEG) as an adhesion promoter. PEG chains can be added to such structures by post-reaction grafting leading to PEG-tethered hydrogels. An additional method is by loading PEG into an already swollen hydrogel structure. In the present work we develop, characterize and evaluate new drug delivery systems containing PEG." "The fracture energy required to separate layers of hydrogel films in control with mucin is investigated to evaluate the impact of promoter chain diffusion on device/mucin adhesion and to obtain molecular information on the fracture energy in drug carrier mucoadhesion. PEG is incorporated in a hydrogel and used as an adhesion promoter. The influence of PEG molecular weight and contact time on PEG diffusion across the hydrogel/mucin interface is investigated by using tensiometry and near-field FTIR microscopy. Fracture analysis provides details about the mechanism of muco-adhesion and conditions of improved adhesion. In our work, we concentrate also on the practical development of such PEG-tethered or PEG-promoted systems for transmucosal, buccal and nasal delivery systems."

描述：研究人员建议开发和研究 亲水性聚合物药物载体的粘膜粘附行为 通过加入聚乙二醇，如通过它们的 摘要： “生物粘附控制药物递送的主要目标是定位 在体内的递送装置，以增强药物吸收过程， 具体的方式。 生物粘附受以下因素的协同作用影响： 生物环境，聚合物的性能控制 释放装置和药物本身的存在。 交货地点和 这种装置的设计是由药物的分子结构及其 药理学行为 我们实验室最近的研究表明， 用作亲水性聚合物结构的特定亲水性聚合物结构的粘膜粘附行为 用于药物递送的载体可以通过加入 聚乙二醇（PEG）作为粘合促进剂。 PEG链可以是 通过反应后接枝添加到这样的结构中，导致PEG-栓系的 水凝胶 另一种方法是通过将PEG加载到已经溶胀的 水凝胶结构。 在目前的工作中，我们开发，表征和 评估含有PEG的新药物递送系统。" “将水凝胶膜层分离所需的断裂能量 研究粘蛋白的控制以评估启动子链的影响 器械/粘蛋白粘附上的扩散，并获得以下分子信息 药物载体粘膜粘附中的断裂能。 PEG被引入到 水凝胶并用作粘合促进剂。 PEG分子量的影响 PEG扩散穿过水凝胶/粘蛋白界面的重量和接触时间 通过使用张力计和近场FTIR显微镜研究。 断裂分析提供了关于粘膜粘附机制的细节， 改善粘合力的条件。 在我们的工作中， 这种PEG栓系或PEG促进的系统的实际开发， 经粘膜、口腔和鼻递送系统。"