VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE

暴力行为、神经递质、葡萄糖代谢和酒精滥用

• 批准号: 3745233
• 负责人: M LINNOILA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745233
• 关键词: aggression; alcoholism /alcohol abuse; behavior prediction; cerebrospinal fluid; circadian rhythms; criminology; family genetics; glucose metabolism; glucose tolerance test; human subject; hydroxyindoleacetate; hypoglycemia; longitudinal human study; neuropsychology; neurotransmitter metabolism; obsessive compulsive disorder; relapse /recurrence; serotonin; violence

We have investigated neurotransmitter metabolites and glucose metabolism in incarcerated violent offenders, arsonists and healthy volunteers. We have found that low cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5HIAA) concentrations and hypoglycemia during oral glucose tolerance tests are associated with each other and impulsive violent acts and fire setting. In a follow-up study, we found that a low blood glucose nadir and low CSF 5HIAA concentration were powerful predictors of recidivism among impulsive violent offenders and fire setters. We are currently collecting lymphocytes for molecular genetic studies from violent offenders, their family members and appropriate controls.

我们研究了神经递质代谢物和葡萄糖代谢 在被监禁的暴力罪犯纵火犯和健康的志愿者中。 我们 已经发现，低脑脊液（CSF），5-羟基吲哚乙酸， 口服葡萄糖耐量期间的（5 HIAA）浓度和低血糖 测试是与对方和冲动的暴力行为和火灾 设置. 在一项后续研究中，我们发现低血糖最低点 脑脊液中5-HIAA浓度低是再次犯罪的有力预测因素 冲动的暴力犯罪者和纵火犯 我们目前正在 收集淋巴细胞进行分子遗传学研究， 罪犯、其家庭成员和适当的控制。