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CSF NEUROPEPTIDES IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE

CSF NEUROPEPTIDES IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE
酒精戒断和脑部疾病中的脑脊液神经肽
批准号：
3801946
负责人：
M LINNOILA
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3801946
关键词：
3 methoxy 4 hydroxyphenylethyleneglycol alcoholism /alcohol abuse alcoholism /alcohol abuse chemotherapy brain disorders cerebrospinal fluid clinical chemistry drug withdrawal ethanol human subject interview neuropeptides neurotransmitter metabolism neurotransmitters norepinephrine

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中文摘要
翻译
酒精戒断症状的严重程度在酗酒者中进行了量化 在华盛顿退伍军人医院神经科病房住院。 脑脊液（CSF）样本重复获得早期在 在所有症状消退后停药。 浓度的 单胺类神经递质去甲肾上腺素及其主要代谢产物MHPG 在NIH进行测量。 观察到显著正相关 去甲肾上腺素周转率升高的指数与 戒酒 我们目前正在测量已知的 与去甲肾上腺素同时在突触中释放。 我们正在继续 来增加样本量
英文摘要
Severity of withdrawal symptoms from alcohol was quantified in alcoholics admitted to the Neurology Ward of the Washington, DC VA Hospital. Cerebrospinal fluid (CSF) samples were repeatedly obtained early during withdrawal after all symptoms had subsided. Concentrations of the monoamine neurotransmitter norepinephrine and its major metabolite MHPG were measured at NIH. Significant positive correlations were observed between indices of elevated norepinephrine turnover and several signs of alcohol withdrawal. We are currently measuring peptides known to be released in synapses simultaneously with norepinephrine. We are continuing to increase our sample size.
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VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE
CSF NEUROPEPTIDES AND PROSTAGLANDINS IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE
VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE
CSF NEUROPEPTIDES AND PROSTAGLANDINS IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE