CSF NEUROPEPTIDES IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE

酒精戒断和脑部疾病中的脑脊液神经肽

• 批准号: 3801946
• 负责人: M LINNOILA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3801946
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; alcoholism /alcohol abuse; alcoholism /alcohol abuse chemotherapy; brain disorders; cerebrospinal fluid; clinical chemistry; drug withdrawal; ethanol; human subject; interview; neuropeptides; neurotransmitter metabolism; neurotransmitters; norepinephrine

Severity of withdrawal symptoms from alcohol was quantified in alcoholics admitted to the Neurology Ward of the Washington, DC VA Hospital. Cerebrospinal fluid (CSF) samples were repeatedly obtained early during withdrawal after all symptoms had subsided. Concentrations of the monoamine neurotransmitter norepinephrine and its major metabolite MHPG were measured at NIH. Significant positive correlations were observed between indices of elevated norepinephrine turnover and several signs of alcohol withdrawal. We are currently measuring peptides known to be released in synapses simultaneously with norepinephrine. We are continuing to increase our sample size.

酒精戒断症状的严重程度在酗酒者中被量化 住进了华盛顿特区退伍军人医院的神经科病房。 早期反复采集脑脊液(CSF)样本 在所有症状都消退后停药。的浓度。 单胺类神经递质去甲肾上腺素及其主要代谢物MHPG 在美国国立卫生研究院进行了测量。观察到显著的正相关。 在去甲肾上腺素周转率升高的指标和几个指标之间 戒酒。我们目前正在测量已知的多肽 与去甲肾上腺素同时在突触中释放。我们还在继续 以增加我们的样本量。