CSF NEUROPEPTIDES AND PROSTAGLANDINS IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE

脑脊液神经肽和前列腺素在酒精戒断和脑疾病中的作用

• 批准号: 3822963
• 负责人: M LINNOILA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3822963
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; alcoholism /alcohol abuse; alcoholism /alcohol abuse chemotherapy; cerebrospinal fluid; clinical chemistry; diazepam; drug withdrawal; ethanol; human subject; human tissue; interview; neurotransmitter metabolism; norepinephrine; prostaglandins

Severity of withdrawal symptoms from alcohol was quantified in alcoholics admitted to the Neurology Ward of the Washington, D.C. VA Hospital. Cerebrospinal fluid (CSF) samples were repeatedly obtained early during withdrawal and after all symptoms had subsided. Concentrations of the monoamine neurotransmitter norepinephrine and its major metabolite MHPG were measured at NIH. Significant positive correlations were observed between indices of elevated norepinephrine turnover and several signs of alcohol withdrawal. A manuscript on the norepinephrine findings is in press in Archives of General Psychiatry. We are continuing this work trying to identify causes for the noradrenergic dysregulation during alcohol withdrawal. Thus, we are measuring peptides and prostaglandins, known to participate in the regulation of the functioning of noradrenergic synapses simultaneously with norepinephrine. We are correlating the concentrations of these neuromodulators to concentrations of norepinephrine and MHPG in the CSF and to the severity of withdrawal symptoms in our patients.

酒精戒断症状的严重程度在酗酒者中进行了量化 入住华盛顿，华盛顿特区VA医院神经科病房。 脑脊液（CSF）样本重复获得早期在 停药后，所有症状消退。 浓度的 单胺类神经递质去甲肾上腺素及其主要代谢产物MHPG 在NIH进行测量。 观察到显著正相关 去甲肾上腺素周转率升高的指数与 戒酒 关于去甲肾上腺素发现的手稿已发表 《普通精神病学档案》中的新闻。 我们正在继续这项工作 试图找出去甲肾上腺素能失调的原因， 戒酒 因此，我们测量的是肽和胰高血糖素， 已知参与调节去甲肾上腺素能 与去甲肾上腺素同时突触。 我们正在将 这些神经调质的浓度与去甲肾上腺素的浓度 和MHPG在CSF中，并在我们的戒断症状的严重程度， 患者