VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE

我们研究了神经递质代谢物和葡萄糖代谢 在被监禁的暴力罪犯纵火犯和健康的志愿者中。 我们发现低浓度的脑脊液（CSF）、5-羟基吲哚乙酸 酸（5-HIAA）浓度和口服葡萄糖期间的低血糖 耐受性测试与彼此冲动的暴力行为有关 和放火 在一项后续研究中，我们发现， 血糖最低值和低CSF 5-HIAA浓度是强有力的预测因子 冲动的暴力犯罪者和纵火犯的累犯率。 我们 已经记录了一种严重的昼夜活动节律紊乱， 间歇性爆发性精神障碍的酗酒暴力罪犯 的 酒精中毒患者与低CSF 5-HIAA相关的人格异常 暴力罪犯被发现是慢性易怒， 精神衰弱 分子遗传家族研究的样本采集 关于酗酒暴力罪犯的调查已经完成 临床资料 在精神病诊断和所有生化和 生理数据已经输入电脑并进行了复查 错误。 分子遗传学分析实验室 神经化学正在进行中。

We have investigated neurotransmitter metabolites and glucose metabolism in incarcerated violent offenders, arsonists, and healthy volunteers. We have found that low cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) concentrations, and hypoglycemia during oral glucose tolerance tests are associated with each other and impulsive violent acts and fire setting. In a follow-up study, we found that a low blood glucose nadir and low CSF 5-HIAA concentration were powerful predictors of recidivism among impulsive violent offenders and fire setters. We have documented a profound disturbance of day-night activity rhythms in alcoholic violent offenders with intermittent explosive disorder. The personality abnormalities associated with low CSF 5-HIAA in alcoholic violent offenders were found to be chronic irritability and psychasthenia. Sample collection for the molecular genetic family study on alcoholic violent offenders has been completed. The clinical data have been blind rated for psychiatric diagnoses and all biochemical and physiological data have been entered in the computers and double checked for errors. Molecular genetic analyses in the Laboratory of Neurochemistry are underway.