VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE

我们研究了神经递质代谢物和葡萄糖代谢。 在被监禁的暴力罪犯、纵火犯和健康志愿者中。 我们发现低位脑脊液(CSF)、5-羟基吲哚乙酸 5-HIAA浓度与口服葡萄糖时的低血糖 耐受性测试与冲动的暴力行为 和着火装置。阐明反应性脑损伤的病理生理机制 间接量热法用于低血糖、血糖升高的胰岛素钳夹研究 已经在40多名罪犯和健康志愿者身上进行了测试。这个 数据尚未分析，因为最初的功率计算表明 更大的样本量是必要的。对象的样例集合 对酗酒暴力犯的分子遗传学家系研究已经完成 完成。临床数据已被盲目评定为精神疾病 诊断和所有生化和生理数据都已输入 并仔细检查是否有错误。分子遗传学 神经遗传学实验室的分析正在进行中。十三 数百个DNA样本，代表芬兰人的随机样本， 没有标识，是从Leena Peltoven博士那里收到的 赫尔辛基国立公共卫生研究所。和我们自己的一起 对照样本由300名志愿者组成，这些样本将被 用于确定罕见多态的真实等位基因频率 在芬兰人口中。

We have investigated neurotransmitter metabolites and glucose metabolism in incarcerated violent offenders, arsonists, and healthy volunteers. We have found that low cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) concentrations, and hypoglycemia during oral glucose tolerance tests are associated with each other and impulsive violent acts and fire setting. To elucidate the pathophysiology of the reactive hypoglycemia, englycemic insulin clamp studies with indirect calorimetry have been performed on more than 40 offenders and healthy volunteers. The data have not been analyzed, because initial power calculations indicated that a larger sample size is necessary. Sample collection for the molecular genetic family study on alcoholic violent offenders has been completed. The clinical data have been blind rated for psychiatric diagnoses and all biochemical and physiological data have been entered in the computers and double checked for errors. Molecular genetic analyses in the Laboratory of Neurogenetics are underway. Thirteen hundred DNA samples, which represent a random sample of Finns, and which are without identifiers, were received from Dr. Leena Peltoven in the National Public Health Institute in Helsinki. Together with our own control sample which consists of 300 volunteers, these samples will be used to establish the true allelic frequencies of rare polymorphisms among the Finnish population.