EXERCISE AND WELL-BEING IN WOMEN WITH SICKLE CELL ANEMIA

镰状细胞性贫血女性的锻炼和健康

• 批准号: 2026378
• 负责人: Bernard Gutin
• 金额: $ 14.41万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2026378
• 关键词: body composition; calorimetry; clinical research; echocardiography; exercise; female; health surveys; heart function; human subject; human therapy evaluation; muscle strength; oxygen consumption; physical therapy; radiography; sickle cell anemia

DESCRIPTION (Adapted from the Applicant's Description): The proposed study's long-term goal is to determine the value of exercise for patients with sickle cell anemia (SCA). This disability is characterized by sedentariness, partly because of limitations imposed by the disability and partly because of medical conservatism. Since no information exists concerning controlled physical training (PT) in SCA patients, it is difficult for physicians to make informed recommendations to their patients concerning the value or danger of exercise. Specific aim: To determine the effect of PT on physical fitness and well-being of SCA patients. Main measurements: The primary outcome variable will be peak oxygen consump-tion. Anaerobic threshold, a submaximal and effort-independent measurement, will be used as a secondary index of aerobic fitness. The investigator will also measure muscle strength with leg and bench press tests, left ventricular dimensions and function with echocardiography, perception of well-being with the Rand-SF36 survey, and body composition with dual x-ray absorptometry. To help interpret body composition changes, he will measure resting energy expenditure by indirect calorimetry, diet with three day recalls, and free-living physical activity by seven day recall. Design: Female SCA patients (n=64) will be randomized into two groups. Group 1 will engage in PT for six months while group 2 continues in their standard care. The primary hypothesis will be tested with a random group analysis, using the "intention to treat" procedure. Physical training: PT sessions will be offered four times a week; the intent will be to have each woman attend at least three times a week. PT sessions will be comprised of aerobic and strength training. The subjects will wear heart rate monitors throughout the sessions to monitor exercise intensity, which will be kept below the level at which any undesirable signs or symptoms were observed on the baseline exercise test. Implication: This study is intended to provide new information about the effectiveness of regular exercise in improving the health and well-being of women with SCA.

描述（改编自申请人的描述）：所提出的 这项研究的长期目标是确定运动对患者的价值 镰状细胞性贫血（SCA） 这种残疾的特点是： 久坐不动，部分原因是残疾和 部分原因是医学保守主义。 由于没有任何信息 关于SCA患者的受控体能训练（PT）， 医生很难向病人提出明智的建议 关于运动的价值或危险。 具体目的：确定PT对体能的影响， SCA患者的健康。 主要测量指标：主要结局变量为峰值氧含量 消费 无氧阈值，一个次最大和努力无关 测量，将被用作有氧健身的次要指标。 的 研究者还将测量腿部和卧推的肌肉力量 超声心动图检查，左心室尺寸和功能， Rand-SF 36调查的幸福感，以及身体成分 用双X射线照相术。 为了帮助解释身体成分的变化， 他将通过间接测热法，饮食， 三天的回忆，七天的自由生活体力活动， 记得了 设计：女性SCA患者（n=64）将被随机分为两组。 第一组将进行为期六个月的PT，而第二组将继续进行他们的 标准护理 主要假设将通过随机分组进行检验 分析，使用“意向治疗”程序。 体能训练：每周四次体能训练; 目的是让每个妇女每周至少参加三次。 PT 课程将包括有氧和力量训练。 受试者 将在整个训练过程中佩戴心率监测器， 而这一点，也将在未来的发展中，被人们所关注。 或在基线运动试验中观察到症状。 含义：本研究旨在提供有关 定期锻炼对改善老年人健康和福祉的有效性 SCA的女性

项目成果

Body composition in women with sickle cell disease.

患有镰状细胞病的女性的身体成分。

• 发表时间: 2001
• 期刊: Ethnicity & disease.
• 作者: Woods,KF;Ramsey,LT;Callahan,LA;Mensah,GA;Litaker,MS;Kutlar,A;Barbeau,P;Gutin,B
• 通讯作者: Gutin,B