LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS

青少年的生活方式、肥胖和心血管健康

• 批准号: 6527295
• 负责人: Bernard Gutin
• 金额: $ 63.87万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527295
• 关键词: adolescence (12-20); behavioral /social science research tag; body composition; cardiovascular disorder; cardiovascular function; cardiovascular stress test; clinical research; diet; disease /disorder proneness /risk; exercise; gender difference; health behavior; human subject; lifestyle; magnetic resonance imaging; obesity; photon absorptiometry; racial /ethnic difference; socioeconomics

DESCRIPTION: (Adapted from the Investigator's Abstract) Rationale and long-term objectives: Adult studies have shown that adiposity, especially visceral adipose tissue (VAI), and cardiovascular (CV) fitness are key links between lifestyle factors like diet and exercise on one hand, and CV disease on the other. However, very little is known about these links during the juvenile years, when the processes leading to CV disease are at an early stage of development. The specific aims are as follow: (1) to determine the relations of free-living diet and exercise to total body percent fat ( percentBF), VAT and CV fitness in black and white boys and girls of varying SES. (2) to determine the relations of fatness and fitness to different CVD risk factors. Design and methods: (1) Recruit 800 15 to 18 year olds, 200 in each ethnicity and gender subgroup. (2) Assess diet with seven 24-hour recalls, and exercise with two seven-day recalls and heart rate monitoring. (3) Measure percent body fat with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging and CV fitness with a multi-stage treadmill test. (4) Measure major fatness- and fitness-related CV disease risk factors (e.g., total cholesterol:HDL cholesterol ratio, insulin, systolic blood pressure, left ventricular mass indexed to height, fibrinogen). (5) Conduct multivariate and univariate analyses to determine relationships. Health relatedness: The investigators state that the provided by this project will assist in the formulation of effective lifestyle interventions targeted to specific demographic groups for primary prevention of CVD, starting early in life when the foundations for adult disease are being laid.

描述：（改编自研究者的摘要）基本原理和长期 目标：成人研究表明肥胖，尤其是内脏肥胖 脂肪组织 (VAI) 和心血管 (CV) 健康是两者之间的关键联系 一方面是饮食和锻炼等生活方式因素，另一方面是心血管疾病 其他。然而，在青少年时期，人们对这些联系知之甚少。 年，当导致心血管疾病的过程处于早期阶段时 发展。 具体目的如下：（1）确定自由生活关系 饮食和运动对全身脂肪百分比 (%BF)、增值税和 CV 健身的影响 不同社会经济地位的黑人和白人男孩和女孩。 (2)确定关系 肥胖和健康对不同 CVD 危险因素的影响。 设计与方法：（1）招募800名15至18岁青少年，每个民族200名 和性别亚组。 (2) 通过 7 次 24 小时回忆来评估饮食和运动 两次 7 天召回和心率监测。 (3) 测量身体百分比 双能 X 射线吸收法测定脂肪，磁共振成像增值税 以及多阶段跑步机测试的 CV 适应性。 (4) 测量主要脂肪—— 以及与健身相关的心血管疾病危险因素（例如总胆固醇：HDL 胆固醇比率、胰岛素、收缩压、左心室质量 以身高、纤维蛋白原为索引）。 (5) 进行多变量和单变量 分析以确定关系。 健康相关性：调查人员表示，该项目提供的 将协助制定有效的生活方式干预措施 特定人群的 CVD 一级预防，从早期开始 当成人疾病的基础正在奠定时的生活。