LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS

青少年的生活方式、肥胖和心血管健康

• 批准号: 6197518
• 负责人: Bernard Gutin
• 金额: $ 61.92万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6197518
• 关键词: adolescence (12-20); behavioral /social science research tag; body composition; cardiovascular disorder; cardiovascular function; cardiovascular stress test; clinical research; diet; disease /disorder proneness /risk; exercise; gender difference; health behavior; human subject; lifestyle; magnetic resonance imaging; obesity; photon absorptiometry; racial /ethnic difference; socioeconomics

DESCRIPTION: (Adapted from the Investigator's Abstract) Rationale and long-term objectives: Adult studies have shown that adiposity, especially visceral adipose tissue (VAI), and cardiovascular (CV) fitness are key links between lifestyle factors like diet and exercise on one hand, and CV disease on the other. However, very little is known about these links during the juvenile years, when the processes leading to CV disease are at an early stage of development. The specific aims are as follow: (1) to determine the relations of free-living diet and exercise to total body percent fat ( percentBF), VAT and CV fitness in black and white boys and girls of varying SES. (2) to determine the relations of fatness and fitness to different CVD risk factors. Design and methods: (1) Recruit 800 15 to 18 year olds, 200 in each ethnicity and gender subgroup. (2) Assess diet with seven 24-hour recalls, and exercise with two seven-day recalls and heart rate monitoring. (3) Measure percent body fat with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging and CV fitness with a multi-stage treadmill test. (4) Measure major fatness- and fitness-related CV disease risk factors (e.g., total cholesterol:HDL cholesterol ratio, insulin, systolic blood pressure, left ventricular mass indexed to height, fibrinogen). (5) Conduct multivariate and univariate analyses to determine relationships. Health relatedness: The investigators state that the provided by this project will assist in the formulation of effective lifestyle interventions targeted to specific demographic groups for primary prevention of CVD, starting early in life when the foundations for adult disease are being laid.

描述：（改编自研究者摘要）原理和长期 目的：成人研究表明，肥胖，特别是内脏 脂肪组织（VAI）和心血管（CV）健康是 一方面是生活方式因素，如饮食和运动，另一方面是CV疾病。 其他.然而，很少有人知道这些联系在少年时期， 年，当导致CV疾病的过程处于早期阶段时， 发展 其具体目的是：（1）确定自由生活的关系 饮食和运动对总身体脂肪百分比（TBF），VAT和CV健身的影响 不同社会地位的黑人和白色男孩和女孩。(2)来确定 肥胖和健康对不同心血管疾病危险因素的影响。 研究设计与方法：（1）招募15 ~ 18岁青少年800名，各民族200名 性别分组。(2)通过7次24小时回忆评估饮食和运动 两次七天召回和心率监测(3)测量身体百分比 脂肪双能X线吸收法，VAT磁共振成像 和CV适应性进行多阶段跑步机测试。(4)测量主要脂肪- 和健康相关的CV疾病风险因素（例如，总胆固醇：HDL 胆固醇比率，胰岛素，收缩压，左心室质量 以身高、纤维蛋白原为指标）。(5)进行多变量和单变量 分析以确定关系。 健康相关性：研究者指出，本项目提供的 将协助制定有效的生活方式干预措施， 特定的人口统计学群体，用于CVD的一级预防， 当成人疾病的基础正在奠定时，生活。