LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS

青少年的生活方式、肥胖和心血管健康

• 批准号: 6650861
• 负责人: Bernard Gutin
• 金额: $ 64.53万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650861
• 关键词: adolescence (12-20); behavioral /social science research tag; body composition; cardiovascular disorder; cardiovascular function; cardiovascular stress test; clinical research; diet; disease /disorder proneness /risk; exercise; gender difference; health behavior; human subject; lifestyle; magnetic resonance imaging; obesity; photon absorptiometry; racial /ethnic difference; socioeconomics

DESCRIPTION: (Adapted from the Investigator's Abstract) Rationale and long-term objectives: Adult studies have shown that adiposity, especially visceral adipose tissue (VAI), and cardiovascular (CV) fitness are key links between lifestyle factors like diet and exercise on one hand, and CV disease on the other. However, very little is known about these links during the juvenile years, when the processes leading to CV disease are at an early stage of development. The specific aims are as follow: (1) to determine the relations of free-living diet and exercise to total body percent fat ( percentBF), VAT and CV fitness in black and white boys and girls of varying SES. (2) to determine the relations of fatness and fitness to different CVD risk factors. Design and methods: (1) Recruit 800 15 to 18 year olds, 200 in each ethnicity and gender subgroup. (2) Assess diet with seven 24-hour recalls, and exercise with two seven-day recalls and heart rate monitoring. (3) Measure percent body fat with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging and CV fitness with a multi-stage treadmill test. (4) Measure major fatness- and fitness-related CV disease risk factors (e.g., total cholesterol:HDL cholesterol ratio, insulin, systolic blood pressure, left ventricular mass indexed to height, fibrinogen). (5) Conduct multivariate and univariate analyses to determine relationships. Health relatedness: The investigators state that the provided by this project will assist in the formulation of effective lifestyle interventions targeted to specific demographic groups for primary prevention of CVD, starting early in life when the foundations for adult disease are being laid.

描述：（改编自研究者摘要）基本原理和长期

项目成果

High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents.

• DOI: 10.1038/ijo.2015.51
• 发表时间: 2015-08
• 期刊: International journal of obesity (2005)
• 作者: Zhu H;Bhagatwala J;Pollock NK;Parikh S;Gutin B;Stallmann-Jorgensen I;Thomas J;Harshfield GA;Dong Y
• 通讯作者: Dong Y

Phylloquinone Intake Is Associated with Cardiac Structure and Function in Adolescents.

叶绿醌的摄入量与青少年的心脏结构和功能有关。

• DOI: 10.3945/jn.117.253666
• 发表时间: 2017
• 期刊: The Journal of nutrition
• 作者: Douthit,MaryK;Fain,MaryEllen;Nguyen,JoshuaT;Williams,CelestineF;Jasti,AllisonH;Gutin,Bernard;Pollock,NormanK
• 通讯作者: Pollock,NormanK

Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activity.

• DOI: 10.1016/j.jpeds.2010.08.007
• 发表时间: 2011-02
• 期刊: The Journal of pediatrics
• 作者: Zhu H;Wang X;Gutin B;Davis CL;Keeton D;Thomas J;Stallmann-Jorgensen I;Mooken G;Bundy V;Snieder H;van der Harst P;Dong Y
• 通讯作者: Dong Y

Race/Ethnicity-Specific Association of Vitamin D and Global DNA Methylation: Cross-Sectional and Interventional Findings.

维生素 D 与全球 DNA 甲基化的种族/民族特异性关联：横断面和干预研究结果。

• DOI: 10.1371/journal.pone.0152849
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zhu,Haidong;Bhagatwala,Jigar;Huang,Ying;Pollock,NormanK;Parikh,Samip;Raed,Anas;Gutin,Bernard;Harshfield,GregoryA;Dong,Yanbin
• 通讯作者: Dong,Yanbin

Adolescent obesity, bone mass, and cardiometabolic risk factors.

• DOI: 10.1016/j.jpeds.2010.11.052
• 发表时间: 2011-05
• 期刊: JOURNAL OF PEDIATRICS
• 影响因子: 5.1
• 作者: Pollock, Norman K.;Bernard, Paul J.;Gutin, Bernard;Davis, Catherine L.;Zhu, Haidong;Dong, Yanbin
• 通讯作者: Dong, Yanbin