LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS

青少年的生活方式、肥胖和心血管健康

• 批准号: 6390601
• 负责人: Bernard Gutin
• 金额: $ 65.14万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390601
• 关键词: adolescence (12-20); behavioral /social science research tag; body composition; cardiovascular disorder; cardiovascular function; cardiovascular stress test; clinical research; diet; disease /disorder proneness /risk; exercise; gender difference; health behavior; human subject; lifestyle; magnetic resonance imaging; obesity; photon absorptiometry; racial /ethnic difference; socioeconomics

DESCRIPTION: (Adapted from the Investigator's Abstract) Rationale and long-term objectives: Adult studies have shown that adiposity, especially visceral adipose tissue (VAI), and cardiovascular (CV) fitness are key links between lifestyle factors like diet and exercise on one hand, and CV disease on the other. However, very little is known about these links during the juvenile years, when the processes leading to CV disease are at an early stage of development. The specific aims are as follow: (1) to determine the relations of free-living diet and exercise to total body percent fat ( percentBF), VAT and CV fitness in black and white boys and girls of varying SES. (2) to determine the relations of fatness and fitness to different CVD risk factors. Design and methods: (1) Recruit 800 15 to 18 year olds, 200 in each ethnicity and gender subgroup. (2) Assess diet with seven 24-hour recalls, and exercise with two seven-day recalls and heart rate monitoring. (3) Measure percent body fat with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging and CV fitness with a multi-stage treadmill test. (4) Measure major fatness- and fitness-related CV disease risk factors (e.g., total cholesterol:HDL cholesterol ratio, insulin, systolic blood pressure, left ventricular mass indexed to height, fibrinogen). (5) Conduct multivariate and univariate analyses to determine relationships. Health relatedness: The investigators state that the provided by this project will assist in the formulation of effective lifestyle interventions targeted to specific demographic groups for primary prevention of CVD, starting early in life when the foundations for adult disease are being laid.

描述：(改编自《调查者摘要》)基本原理和长期计划 目的：成人研究表明肥胖症，特别是内脏肥胖症 脂肪组织(VAI)和心血管健康(CV)是 一方面是饮食和锻炼等生活方式因素，另一方面是心血管疾病 其他的。然而，人们对青少年时期的这些联系知之甚少。 导致心血管疾病的过程处于早期阶段的年份 发展。 具体目标如下：(1)确定自由生活的关系 饮食和运动对总体脂百分比(BF)、增值税和心血管健康的影响 黑人和白人的男孩和女孩，不同的SES。(二)确定关系 对不同的心血管疾病危险因素的肥胖和适合度。 设计和方法：(1)招募800名15-18岁的青少年，每个种族200人 和性别亚群。(2)通过七次24小时回忆和锻炼来评估饮食 有两次七天的召回和心率监测。(3)测量人体百分数 脂肪采用双能x射线吸收法，VAT采用核磁共振成像 并通过多阶段跑步机测试进行CV健身。(4)量度主要肥胖度- 和健康相关的心血管疾病风险因素(例如，总胆固醇：高密度脂蛋白 胆固醇比率、胰岛素、收缩压、左心室重量 以身高、纤维蛋白原为指标)。(5)进行多变量和单变量 分析以确定关系。 与健康相关：调查人员表示，该项目提供的 将协助制定有效的生活方式干预措施，旨在 心血管疾病初级预防的特定人口群体，早在#年就开始 当成人疾病的基础正在奠定时的生活。