COMPARATIVE MEDICINE RESEARCH CENTER

比较医学研究中心的长期目标是 密苏里州大学兽医病理学系 哥伦比亚将加强生物医学研究的进展， 通过提高质量和定义来改善人类状况 实验室动物通过基础和应用生物医学研究相关 实验动物医学病理学和科学 历史上， 生物医学研究的进展涉及动物。 动物被利用 在NIH资助的所有研究中大约有一半。 通过提高我们 了解生物学，病理生理学，疾病和研究 使用动物“试剂”外推动物更有意义 衍生数据用于人类健康和疾病将成为可能。 我们的具体 目标包括：1）重点调查，以提供了解， 当代影响使用生物技术的主要问题的可能解决办法 研究中的动物; 2）通过以下方式传播这些信息 适当的出版物和介绍;以及3）协助 应用我们的研究成果。 另一个目的是提供 研究培训机会，并鼓励广泛的教育 实验动物科学领域。 我们已经确定了六个影响动物使用的主要问题， 研究，并在本提案中，我们提出了研究项目的设计 为他们在以下项目下的研究：1）啮齿动物孤儿 细小病毒的分子生物学特性及其诊断方法的研究进展 试剂，2）啮齿动物孤儿细小病毒：致病机制和干扰 与研究，3）肠道的生物学，分段，丝状 啮齿动物的细菌，4）生产用作 使用杆状病毒表达系统的诊断试剂，5）病毒基因 扩增试验用于检测生物制品中的鼠病毒 样品和6）纤毛相关呼吸道芽孢杆菌的发病机理 感染 要求设立一个核心支助股，提供行政服务， 数量有限的机构研究相关实验动物 诊断问题解决服务，其研究计划，以确定 动物健康问题。

The long-term objective of the Comparative Medicine Research Center in the Department of Veterinary Pathology at the University of Missouri- Columbia is to enhance advances in biomedical research and thereby improve the human condition by improving the quality and definition of laboratory animals through basic and applied biomedical research related to laboratory animal medicine, pathology, and science. Historically, progress in biomedical research has involved animals. Animals are used in about half of all research funded by the NIH. By improving our understanding of the biology, pathophysiology, diseases, and research uses of the animal "reagent" more meaningful extrapolation of animal derived data to human health and disease will be possible. Our specific aims include; 1) focused investigations to provide understanding and possible solutions to major contemporary problems affecting the use of animals in research; 2) dissemination of this information through appropriate publications and presentations; and 3) to assist in the application of our research findings. Another aim is to provide research training opportunities and to encourage education in the broad area of laboratory animal science. We have identified six major problems that affect the use of animals in research and in this proposal we present designs of research projects for their study under the following project titles: 1) Rodent Orphan Parvoviruses: Molecular Characterization and Development of Diagnostic Reagents, 2) Rodent Orphan Parvoviruses: Pathogenesis and Interference with Research, 3) The biology of the Intestinal, Segmented, Filamentous Bacteria of Rodents, 4) Production of Specific viral Antigens for Use as Diagnostic Reagents Using a Baculovirus Expression System, 5) Viral Gene Amplification Assays for Detection of Murine Viruses in Biological Samples, and 6) Pathogenesis of Cilia-Associated Respiratory Bacillus Infection. A CORE Support Unit is requested to provide administrative services and a limited amount of institutional research-related laboratory animal diagnostic problem solving services for its research program to identify animal health problems.