COMPARATIVE MEDICINE RESEARCH CENTER

年比较医学研究中心的长期目标 密苏里大学兽医病理学系 哥伦比亚大学将加强生物医学研究的进展，从而 通过提高质量和清晰度来改善人类条件 与基础和应用生物医学研究相关的实验动物 实验动物医学、病理学和科学。从历史上看， 生物医学研究的进展涉及动物。动物被用来 在美国国立卫生研究院资助的所有研究中，约有一半是这样的。通过改进我们的 了解生物学、病理生理学、疾病和研究 利用动物的“试剂”更有意义地推断动物 人类健康和疾病的衍生数据将成为可能。我们的特定 目标包括：1)重点调查，以提供了解和 对影响使用的主要当代问题的可能解决办法 研究中的动物；2)通过 适当的出版物和演示文稿；以及3)协助 应用我们的研究成果。另一个目标是提供 研究培训机会并鼓励广泛的教育 实验动物科学领域。 我们已经确定了影响动物使用的六个主要问题 研究，在这份提案中，我们提出了研究项目的设计 以下列项目名称进行研究：1)啮齿动物孤儿 细小病毒的分子特征及其诊断研究进展 试剂，2)啮齿动物孤儿细小病毒：发病机制和干预 通过研究，3)肠道的生物学，分段的，丝状的 啮齿动物的细菌，4)特定病毒抗原的生产 使用杆状病毒表达系统的诊断试剂，5)病毒基因 小鼠体内病毒的扩增检测方法 6)纤毛相关呼吸道芽孢杆菌的致病机理 感染。 请核心支助股提供行政服务，并 与机构研究相关的有限数量的实验动物 为其研究计划提供诊断问题解决服务，以确定 动物健康问题。

The long-term objective of the Comparative Medicine Research Center in the Department of Veterinary Pathology at the University of Missouri- Columbia is to enhance advances in biomedical research and thereby improve the human condition by improving the quality and definition of laboratory animals through basic and applied biomedical research related to laboratory animal medicine, pathology, and science. Historically, progress in biomedical research has involved animals. Animals are used in about half of all research funded by the NIH. By improving our understanding of the biology, pathophysiology, diseases, and research uses of the animal "reagent" more meaningful extrapolation of animal derived data to human health and disease will be possible. Our specific aims include; 1) focused investigations to provide understanding and possible solutions to major contemporary problems affecting the use of animals in research; 2) dissemination of this information through appropriate publications and presentations; and 3) to assist in the application of our research findings. Another aim is to provide research training opportunities and to encourage education in the broad area of laboratory animal science. We have identified six major problems that affect the use of animals in research and in this proposal we present designs of research projects for their study under the following project titles: 1) Rodent Orphan Parvoviruses: Molecular Characterization and Development of Diagnostic Reagents, 2) Rodent Orphan Parvoviruses: Pathogenesis and Interference with Research, 3) The biology of the Intestinal, Segmented, Filamentous Bacteria of Rodents, 4) Production of Specific viral Antigens for Use as Diagnostic Reagents Using a Baculovirus Expression System, 5) Viral Gene Amplification Assays for Detection of Murine Viruses in Biological Samples, and 6) Pathogenesis of Cilia-Associated Respiratory Bacillus Infection. A CORE Support Unit is requested to provide administrative services and a limited amount of institutional research-related laboratory animal diagnostic problem solving services for its research program to identify animal health problems.