PRENATAL CANNABIS AND CIGARETTES-OUTCOMES IN ADOLESCENTS

描述：（申请人摘要） 自1978年以来，一项纵向研究一直在进行调查， 风险人群，大麻和香烟的影响， 怀孕 这项渥太华产前前瞻性研究的总体目的是 （OPPS）是检查这些药物对妊娠，新生儿 以及学龄前和学龄儿童。 本报告的总体目标 竞争性更新是为了确定是否发展后遗症， 在OPPS受试者中观察到的行为困难， 以不同的方式与产前大麻和香烟有关 暴露，坚持在青少年（13-15岁），以及是否，由一个在 深度神经行为评估，更大程度的特异性， 可以识别功能障碍。 由于这种纵向的性质， OPPS，婴儿和幼儿期测试的预测效度可以 也可以检查随着年龄的影响的连续性。 神经行为电池将集中在那些行为， 被确定为易受有关药物影响的人， 在当前资助期间注意到的行为方面 检查9 12 - 12岁的孩子，即子宫内大麻 行政职能和协会的暴露和具体方面 子宫内香烟暴露与语音功能受损之间的关系 语言/阅读、认知和知觉加工形式 涉及对细节的关注。 评估将包括考试 记忆力、注意力、战略规划、语言和阅读方面的能力， 复杂问题的解决和微分过程中涉及的 对刺激的细节方面进行知觉分析。 一 还将区分基本内容中的能力 领域与能力的在线整合等材料， 在能够执行执行功能任务之前需要。 行为，性发育和吸烟和 接触二手烟（使用尿液分析和问卷）将 也可以在青少年中进行评估。 产妇变量（如健康、 营养、平等、教育、年龄、其他药物、智力、个性） 出生后，环境变量将被纳入多变量 统计分析 OPPS是唯一一个公布大麻使用者数据的机构。 儿童期以后的后代，是最全面的纵向 检查吸烟者的学龄儿童。 的测试 青春期中期的儿童尤其重要， 微妙的学习困难最有可能表现出来， 需要集中注意力和认知技能的复杂行为，通常 在目前的发展阶段，可以深入研究。

DESCRIPTION: (Applicant's Abstract) Since 1978, a longitudinal study has been underway investigating, in a low risk population, the effects of marijuana and cigarettes used during pregnancy. The overall purpose of this Ottawa Prenatal Prospective Study (OPPS) is to examine the effects of these drugs on pregnancy, the neonate and the pre-school and school aged offspring. The general objective of this competitive renewal is to determine whether developmental sequelae and behavioral difficulties observed in the OPPS subjects, statistically associated in a differential fashion with prenatal marijuana and cigarette exposure, persist in the adolescent (13-15 year old) and whether, by an in depth neurobehavioral assessment, a greater degree of specificity of dysfunction can be identified. Because of the longitudinal nature of this OPPS, the predictive validity of the infant and early childhood tests can also be examined as can the continuity of effects over age. The neurobehavioral battery will focus upon those behaviors which we have identified to be vulnerable to the drugs in question with an emphasis upon facets of behavior that have been noted in the currently funded period examining 9 1/2 -12 year olds i.e. an association between in utero marijuana exposure and specific aspects of executive function and an association between in utero cigarette exposure and impaired performance in phonological aspects of language/reading, cognition and forms of perceptual processing involving attention to detail. The assessment will include an examination of memory, attention, strategic planning, aspects of language and reading, complex problem solving and the differential processes involved in the perceptual analysis of configural versus detailed aspects of stimuli. A distinction will also be made between the capabilities in basic content domains versus competency in the on-line integration of such material that is required prior to being able to perform executive function tasks. Behavior, sexual development and an assessment of both cigarette smoking and exposure to second hand smoke (using urine analysis and questionnaires) will also be evaluated in the adolescents. Maternal variables (e.g. health, nutrition, parity, education, age, other drugs, intelligence, personality) and postnatal, environmental variables will be included in multivariate statistical analysis. The OPPS is the only work to have published data on marijuana users' offspring beyond early childhood and is the most comprehensive longitudinal work examining school age children of cigarette smokers. The testing of children at mid-adolescence is particularly critical as the identification of subtle learning difficulties is most likely to manifest themselves when complex behaviors requiring focused attention and cognitive skills, normally present at this stage of development, can be examined in depth.