PRENATAL CANNABIS AND CIGARETTES-OUTCOMES IN ADOLESCENTS

青少年产前大麻和香烟的结果

• 批准号: 2458358
• 负责人: PETER A FRIED
• 金额: $ 16.02万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458358
• 关键词: adolescence (12-20); attention; cannabinoids; clinical research; cognition; developmental psychology; embryo /fetus toxicology; female; human subject; language disorders; longitudinal human study; marijuana abuse; memory; nicotine; problem solving; reading; tobacco abuse

DESCRIPTION: (Applicant's Abstract) Since 1978, a longitudinal study has been underway investigating, in a low risk population, the effects of marijuana and cigarettes used during pregnancy. The overall purpose of this Ottawa Prenatal Prospective Study (OPPS) is to examine the effects of these drugs on pregnancy, the neonate and the pre-school and school aged offspring. The general objective of this competitive renewal is to determine whether developmental sequelae and behavioral difficulties observed in the OPPS subjects, statistically associated in a differential fashion with prenatal marijuana and cigarette exposure, persist in the adolescent (13-15 year old) and whether, by an in depth neurobehavioral assessment, a greater degree of specificity of dysfunction can be identified. Because of the longitudinal nature of this OPPS, the predictive validity of the infant and early childhood tests can also be examined as can the continuity of effects over age. The neurobehavioral battery will focus upon those behaviors which we have identified to be vulnerable to the drugs in question with an emphasis upon facets of behavior that have been noted in the currently funded period examining 9 1/2 -12 year olds i.e. an association between in utero marijuana exposure and specific aspects of executive function and an association between in utero cigarette exposure and impaired performance in phonological aspects of language/reading, cognition and forms of perceptual processing involving attention to detail. The assessment will include an examination of memory, attention, strategic planning, aspects of language and reading, complex problem solving and the differential processes involved in the perceptual analysis of configural versus detailed aspects of stimuli. A distinction will also be made between the capabilities in basic content domains versus competency in the on-line integration of such material that is required prior to being able to perform executive function tasks. Behavior, sexual development and an assessment of both cigarette smoking and exposure to second hand smoke (using urine analysis and questionnaires) will also be evaluated in the adolescents. Maternal variables (e.g. health, nutrition, parity, education, age, other drugs, intelligence, personality) and postnatal, environmental variables will be included in multivariate statistical analysis. The OPPS is the only work to have published data on marijuana users' offspring beyond early childhood and is the most comprehensive longitudinal work examining school age children of cigarette smokers. The testing of children at mid-adolescence is particularly critical as the identification of subtle learning difficulties is most likely to manifest themselves when complex behaviors requiring focused attention and cognitive skills, normally present at this stage of development, can be examined in depth.

描述：（申请人摘要） 自 1978 年以来，一项纵向研究一直在进行，调查范围较低 危险人群，吸食大麻和香烟的影响 怀孕。 渥太华产前前瞻性研究的总体目的 (OPPS) 是为了检查这些药物对妊娠、新生儿的影响 以及学龄前和学龄儿童。 本次活动的总体目标 竞争性更新的目的是确定是否存在发育后遗症和 OPPS 受试者中观察到的行为困难，统计数据 以不同的方式与产前大麻和香烟相关 暴露，持续存在于青少年（13-15 岁）以及是否，通过 深度神经行为评估，更大程度的特异性 可以识别功能障碍。 由于其纵向性质 OPPS，婴儿和幼儿测试的预测有效性可以 还可以检查影响随年龄变化的连续性。 神经行为电池将关注我们拥有的那些行为 确定易受相关药物影响，重点是 当前资助期间已注意到的行为的各个方面 检查 9 1/2 -12 岁的儿童，即子宫内大麻之间的关联 执行职能和协会的暴露和具体方面 子宫内香烟暴露与语音表现受损之间的关系 语言/阅读、认知和知觉处理形式的方面 涉及对细节的关注。 评估将包括考试 记忆力、注意力、战略规划、语言和阅读方面， 复杂问题的解决和涉及的不同过程 对刺激的配置与细节方面进行感知分析。 一个 基础内容的能力也会有所区分 在线整合此类材料的领域与能力 在能够执行执行功能任务之前需要。 行为、性发育以及对吸烟和吸烟的评估 接触二手烟（使用尿液分析和问卷调查）会 也可在青少年中进行评估。 母体变量（例如健康状况、 营养、均等、教育、年龄、其他药物、智力、个性） 出生后，环境变量将包含在多元变量中 统计分析。 OPPS 是唯一公布大麻使用者数据的著作 超越幼儿期的后代，是最全面的纵向 对吸烟者的学龄儿童进行检查。 的测试 青春期中期的儿童尤为重要，因为识别 微妙的学习困难最有可能在以下情况下显现出来： 通常需要集中注意力和认知技能的复杂行为 目前发展到这个阶段，可以进行深入研究。