PRENATAL CANNABIS AND CIGARETTES-OUTCOMES IN ADOLESCENTS

青少年产前大麻和香烟的结果

• 批准号: 2458358
• 负责人: PETER A FRIED
• 金额: $ 16.02万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458358
• 关键词: adolescence (12-20); attention; cannabinoids; clinical research; cognition; developmental psychology; embryo /fetus toxicology; female; human subject; language disorders; longitudinal human study; marijuana abuse; memory; nicotine; problem solving; reading; tobacco abuse

DESCRIPTION: (Applicant's Abstract) Since 1978, a longitudinal study has been underway investigating, in a low risk population, the effects of marijuana and cigarettes used during pregnancy. The overall purpose of this Ottawa Prenatal Prospective Study (OPPS) is to examine the effects of these drugs on pregnancy, the neonate and the pre-school and school aged offspring. The general objective of this competitive renewal is to determine whether developmental sequelae and behavioral difficulties observed in the OPPS subjects, statistically associated in a differential fashion with prenatal marijuana and cigarette exposure, persist in the adolescent (13-15 year old) and whether, by an in depth neurobehavioral assessment, a greater degree of specificity of dysfunction can be identified. Because of the longitudinal nature of this OPPS, the predictive validity of the infant and early childhood tests can also be examined as can the continuity of effects over age. The neurobehavioral battery will focus upon those behaviors which we have identified to be vulnerable to the drugs in question with an emphasis upon facets of behavior that have been noted in the currently funded period examining 9 1/2 -12 year olds i.e. an association between in utero marijuana exposure and specific aspects of executive function and an association between in utero cigarette exposure and impaired performance in phonological aspects of language/reading, cognition and forms of perceptual processing involving attention to detail. The assessment will include an examination of memory, attention, strategic planning, aspects of language and reading, complex problem solving and the differential processes involved in the perceptual analysis of configural versus detailed aspects of stimuli. A distinction will also be made between the capabilities in basic content domains versus competency in the on-line integration of such material that is required prior to being able to perform executive function tasks. Behavior, sexual development and an assessment of both cigarette smoking and exposure to second hand smoke (using urine analysis and questionnaires) will also be evaluated in the adolescents. Maternal variables (e.g. health, nutrition, parity, education, age, other drugs, intelligence, personality) and postnatal, environmental variables will be included in multivariate statistical analysis. The OPPS is the only work to have published data on marijuana users' offspring beyond early childhood and is the most comprehensive longitudinal work examining school age children of cigarette smokers. The testing of children at mid-adolescence is particularly critical as the identification of subtle learning difficulties is most likely to manifest themselves when complex behaviors requiring focused attention and cognitive skills, normally present at this stage of development, can be examined in depth.

描述：（申请人的摘要） 自1978年以来，一项纵向研究一直在研究低点 风险种群，大麻和在 怀孕。 这项渥太华产前前瞻性研究的总体目的 （OPP）是检查这些药物对怀孕，新生儿的影响 以及学前班和学校的后代。 这个的总体目标 竞争性更新是为了确定发育后遗症和 在OPPS受试者中观察到的行为困难，统计学上 以不同的方式与产前大麻和香烟相关 曝光，持续到青少年（13-15岁），是否通过 深度神经行为评估，更大程度的特异性 可以识别功能障碍。 因为这是纵向的性质 OPP，婴儿和幼儿测试的预测有效性可以 还可以通过年龄的连续性进行检查。 神经行为电池将集中在我们的行为上 被确定容易受到有关药物的攻击 在当前资助的时期已指出的行为方面 检查9 1/2 -12岁的年轻人，即子宫内大麻之间的关联 曝光和执行功能的特定方面和协会 在子宫烟中的暴露与语音性能受损之间 语言/阅读，认知和感知处理形式的方面 涉及细节的关注。 评估将包括考试 记忆，注意力，战略规划，语言和阅读方面， 复杂的问题解决以及涉及的差异过程 刺激的构型和详细方面的感知分析。 一个 在基本内容中的功能之间也将进行区分 在这种材料的在线整合中的域与能力 在能够执行执行功能任务之前需要。 行为，性发展以及对吸烟和吸烟的评估 暴露于二手烟（使用尿液分析和问卷）将 也可以在青少年中进行评估。 产妇变量（例如健康， 营养，平价，教育，年龄，其他药物，智力，个性） 以及产后，环境变量将包含在多变量中 统计分析。 OPPS是唯一发布有关大麻用户数据的数据的工作 后代以外的童年，是最全面的纵向 检查吸烟者的学龄儿童。 测试 青春期中期的儿童特别关键 微妙的学习困难最有可能表现出来 复杂的行为需要集中注意力和认知能力，通常 在开发阶段存在，可以深入研究。