Prenatal Cannabis & Cigarette Exposure - Outcome

产前大麻

• 批准号: 6775649
• 负责人: PETER A FRIED
• 金额: $ 21.47万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6775649
• 关键词: alcoholism /alcohol abuse; attention; behavioral /social science research tag; clinical research; cognition; disease /disorder proneness /risk; drug /alcohol abstinence; embryo /fetus toxicology; human subject; longitudinal human study; marijuana abuse; memory; neuropsychological tests; peer group; performance; questionnaires; smoking cessation; tobacco abuse; urinalysis; young adult human (21-34)

DESCRIPTION (provided by applicant): Since 1978, a longitudinal study -- the Ottawa Prenatal Prospective Study (OPPS) -- has been investigating a low risk population, the effects of marihuana and cigarettes used during pregnancy. The general objectives of this competitive renewal are twofold and take advantage of the age of the OPPS subjects (20-23 years) who have been assessed since birth. We will continue to assess the young adults focusing upon the domains impacted by either prenatal marihuana or cigarettes at younger ages and examine the predictive validity of the infant and early childhood tests in terms of the continuity of effects over two decades. The second thrust of the proposed work will be to examine parameters related to regular marihuana use by the OPPS offspring, the evaluation of such use upon cognitive performance and an investigation of possible effects after prolonged cessation of regular usage. We have identified, via self-report and urinalysis, that approximately 30 percent of the OPPS 16 1/2 to 19 year old subjects are using marihuana on at least a weekly basis and have been doing so for a year or more. Approximately 20 percent in this age range have used marihuana to that extent in the past but have quit for at least six months. Among these past and present users over half averaged at least 5 joints per week. By using both within and between subject comparisons we will address such question as: whether there are predrug cognitive differences between non-users and future users; whether there is an impact upon cognitive performance that persists beyond the acute intoxication phase either while there may be a drug residue lingering in the CNS or well after such a residue has been cleared. We have the unique opportunity to examine, for the first time within the same subjects, cognitive performance before the initiation of regular marihuana use, during such use and after prolonged cessation. The low-risk nature of the OPPS sample, the vast array of background information, and the longitudinal neuropsychological data spanning infancy to young permits an examination of both the etiology of marihuana use and the consequences on cognitive performance in a manner identified by many researchers as being the pragmatically optimal protocol.

描述（由申请人提供）：自1978年以来，一项纵向研究-

项目成果

Who is it going to be? Subject selection issues in prenatal drug exposure research.

会是谁呢？

• 发表时间: 1992
• 期刊: NIDA research monograph
• 作者: Fried,PA

Prenatal exposure to marihuana and tobacco during infancy, early and middle childhood: effects and an attempt at synthesis.

婴儿期、幼儿期和中期的产前接触大麻和烟草：影响和综合尝试。

• DOI: 10.1007/978-3-642-79451-3_21
• 发表时间: 1995
• 期刊: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
• 作者: Fried,PA

Behavioral outcomes in preschool and school-age children exposed prenatally to marijuana: a review and speculative interpretation.

产前接触大麻的学龄前和学龄儿童的行为结果：回顾和推测性解释。

• 发表时间: 1996
• 期刊: NIDA research monograph.
• 作者: Fried,PA