PRENATAL CANNABIS & CIGARETTE EXPOSURE-LONG TERM EFFECTS

产前大麻

• 批准号: 3210670
• 负责人: PETER A FRIED
• 金额: $ 10.24万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3210670
• 关键词: attention; auditory discrimination; child mental disorders; embryo /fetus drug adverse effect; intelligence; language development; longitudinal human study; marijuana abuse; memory; neuropsychological tests; postnatal growth disorder; preschool child (1-5); problem solving; psychomotor function; sensory discrimination; tobacco abuse; touch; verbal behavior; visual perception

Since 1978, a longitudinal study investigating the effects of marihuana and cigarettes used during pregnancy has been underway. The overall purpose of this Ottawa Prenatal Prospective Study is to examine the effects of these drugs on pregnancy, the neonate and the young child. The general objective of the proposed work is to determine whether particular developmental delays and behavioural difficulties observed in the newborn and infant that are statistically associated with prenatal marihuana and cigarette exposure persist in the 4-6 year old child. Among the marihuana offspring particular attention will be paid to visual functioning, body state alterations and fine motor abilities as these were noted to be altered in the infant. Among the offspring of cigarettes users particular attention will be paid to auditory functioning, motor development and attentional behaviour- all of which were related in infancy to in utero cigarette exposure. The battery at 4 years of age will include an assessment of cognitive performance, motor skills and verbal abilities. At 5 and 6 years of age the battery will include an examination of fine and gross motor abilities, sensory skills (tactile visual and auditory), kinesthetic functioning, visual-spatial capabilities, language skills, reasoning ability, memory (visual, tactile and language), intelligence, academic readiness, phonemic awareness and overall behaviour. Maternal variables (e.g., health, nutrition, parity, age, other drugs) and post-natal variables (e.g. home environment, second-hand smoke, preschool) will be included in multivariate statistical analyses. The Ottawa study is the only work to follow-up marihuana offspring beyond a year of age and is the most comprehensive, longitudinal work examining 4-6 year old children of cigarette smokers. The testing of children of this age is particularly critical as the prediction of subtle learning difficulties is most likely to come from studies of this age group.

自1978年以来，一项纵向研究调查了 怀孕期间使用大麻和香烟， 正在进行中 本渥太华产前检查的总体目的 前瞻性研究是为了检查这些药物对 怀孕、新生儿和幼儿。 总目标 一项拟议工作是确定是否有特定的 发育迟缓和行为困难， 新生儿和婴儿，统计学上与产前 4-6岁的儿童持续接触大麻和香烟。 在大麻后代中， 视觉功能，身体状态改变和精细运动 这些能力在婴儿中被注意到改变。 之间 吸烟者的后代将受到特别关注 听觉功能、运动发展和注意力 行为-所有这些都与婴儿期和子宫内有关 香烟暴露 4岁时的组合将包括以下评估： 认知能力、运动技能和语言能力。 在5和 6岁的电池将包括罚款和 粗大运动能力，感觉技能（触觉、视觉和听觉）， 动觉功能，视觉空间能力，语言能力， 推理能力，记忆力（视觉，触觉和语言）， 智力，学术准备，音素意识和整体 性能. 母体变量（例如，健康、营养、均等、年龄、 其他药物）和产后变量（例如家庭环境， 二手烟，学龄前）将被纳入多变量 统计分析。 渥太华的研究是唯一的后续工作大麻 一岁以上的孩子，是最全面的， 4-6岁儿童吸烟纵向检查 吸烟者。 对这个年龄段的孩子进行测试尤其重要。 关键的是，对微妙的学习困难的预测是最重要的。 可能来自于对这个年龄段的研究。