PRENATAL CANNABIS AND CIGARETTE CONSEQUENCES

产前大麻和香烟的后果

• 批准号: 2117334
• 负责人: PETER A FRIED
• 金额: $ 12.84万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2117334
• 关键词: attention deficit disorder; behavior disorders; child mental disorders; embryo /fetus toxicology; hearing disorders; human subject; language disorders; learning disorders; longitudinal human study; marijuana abuse; memory disorders; middle childhood (6-11); neuropsychological tests; passive smoking; psychomotor disorders; questionnaires; statistics /biometry; tobacco abuse; vision disorders

Since 1978, a longitudinal study investigating the effects of marihuana and cigarettes used during pregnancy has been underway. The overall purpose of this Ottawa Prenatal Prospective Study (OPPS) is to examine the effects of these drugs on pregnancy, the neonate and the child. The general objective of this competitive renewal is to determine whether particular developmental sequelae and behavioral difficulties observed in the newborn, infant, and young child that are statistically associated, in a differential fashion, with prenatal marihuana and cigarette exposure persist in the o 1/2 to 11 year 11 month old child and whether, by an in depth neurobehavioural assessment, a greater degree of specificity of dysfunction can be identified. Additionally, because of the longitudinal nature of this OPPS, the predictive validity of the infant and early childhood tests can be examined as can the continuity of effects over age. The neurobehavioural battery will focus upon those behaviors which we have identified to be vulnerable to the drugs in question. In Particular the assessment will include an examination of language and auditory processing, aspects of reading (including visual and auditory components), visual and non-visual perception, motor tasks, memory tasks, reasoning ability, intelligence, academic readiness, impulsivity sustained attention, psychological status and behavior (as assessed by the parent, teacher and examiner). Material variables (e.g. health, nutrition, parity, education, age, other drugs, intelligence, personality) and postnatal, environmental variables (e.g. home environment, second hand smoke [using urine analysis and questionnaires], and schooling experience) will be included in multivariate statistical analysis. The OPPS is the only work to have published data on marihuana users' offspring beyond a very early childhood and is the most comprehensive longitudinal work examining school age children of cigarette smokers. The testing of children at approximately 10 years of age is particularly critical as the identification of subtle learning difficulties is most likely to manifest themselves when complex behaviors requiring focused attention and cognitive skills, normally present at this stage of development, can be examined in depth.

自1978年以来，一项纵向研究研究了大麻的影响 怀孕期间使用的香烟正在进行中。 总体 这项渥太华产前前瞻性研究（OPP）的目的是检查 这些药物对怀孕，新生儿和儿童的影响。 这 这种竞争性更新的一般目标是确定是否是否 观察到的特定发育后遗症和行为困难 在统计上是新生儿，婴儿和幼儿 以不同的方式与产前大麻和 香烟暴露在O 1/2至11年11个月大的孩子和 是否通过深入的神经性评估，更大程度地 可以识别功能障碍的特异性。 另外，是因为 该OPP的纵向性质，即预测有效性 婴儿和幼儿测试可以像连续性一样检查 超过年龄的影响。 Neurobehavioural电池将集中在我们的行为上 已确定容易受到有关药物的影响。 尤其 评估将包括对语言和听觉的检查 处理，阅读方面（包括视觉和听觉 组件），视觉和非视觉感知，电机任务，内存任务， 推理能力，智慧，学术准备，冲动 持续关注，心理状况和行为（如 父母，老师和考官）。材料变量（例如健康， 营养，平等，教育，年龄，其他药物，智力，智力， 个性）和产后，环境变量（例如，家庭 环境，二手烟[使用尿液分析和问卷]， 和学校经验）将包括在多元统计中 分析。 OPPS是唯一发布有关大麻用户数据的数据 后代超越了很小的童年，是最全面的 纵向工作检查吸烟者的学龄儿童。 尤其是10岁的儿童的测试 至关重要，因为识别微妙的学习困难是最重要的 当需要集中精力的复杂行为时，可能会表现出来 注意力和认知技能，通常在此阶段 开发，可以深入研究。