Prenatal Cannabis & Cigarette Exposure - Outcome

产前大麻

• 批准号: 6466438
• 负责人: PETER A FRIED
• 金额: $ 21.87万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6466438
• 关键词: alcoholism /alcohol abuse; attention; behavioral /social science research tag; clinical research; cognition; disease /disorder proneness /risk; drug /alcohol abstinence; embryo /fetus toxicology; human subject; longitudinal human study; marijuana abuse; memory; neuropsychological tests; peer group; performance; questionnaires; smoking cessation; tobacco abuse; urinalysis; young adult human (21-34)

DESCRIPTION (provided by applicant): Since 1978, a longitudinal study -- the Ottawa Prenatal Prospective Study (OPPS) -- has been investigating a low risk population, the effects of marihuana and cigarettes used during pregnancy. The general objectives of this competitive renewal are twofold and take advantage of the age of the OPPS subjects (20-23 years) who have been assessed since birth. We will continue to assess the young adults focusing upon the domains impacted by either prenatal marihuana or cigarettes at younger ages and examine the predictive validity of the infant and early childhood tests in terms of the continuity of effects over two decades. The second thrust of the proposed work will be to examine parameters related to regular marihuana use by the OPPS offspring, the evaluation of such use upon cognitive performance and an investigation of possible effects after prolonged cessation of regular usage. We have identified, via self-report and urinalysis, that approximately 30 percent of the OPPS 16 1/2 to 19 year old subjects are using marihuana on at least a weekly basis and have been doing so for a year or more. Approximately 20 percent in this age range have used marihuana to that extent in the past but have quit for at least six months. Among these past and present users over half averaged at least 5 joints per week. By using both within and between subject comparisons we will address such question as: whether there are predrug cognitive differences between non-users and future users; whether there is an impact upon cognitive performance that persists beyond the acute intoxication phase either while there may be a drug residue lingering in the CNS or well after such a residue has been cleared. We have the unique opportunity to examine, for the first time within the same subjects, cognitive performance before the initiation of regular marihuana use, during such use and after prolonged cessation. The low-risk nature of the OPPS sample, the vast array of background information, and the longitudinal neuropsychological data spanning infancy to young permits an examination of both the etiology of marihuana use and the consequences on cognitive performance in a manner identified by many researchers as being the pragmatically optimal protocol.

描述（由申请人提供）：自1978年以来，一项纵向研究 - 渥太华产前前瞻性研究（OPPS） - 一直在研究低风险 人口，大麻和怀孕期间使用的香烟的影响。这 这种竞争性更新的一般目标是双重的，并利用 自从接受评估的OPPS受试者（20-23岁）的年龄 出生。我们将继续评估专注于领域的年轻人 受产前大麻或年轻时的香烟的影响并检查 婴儿和儿童早期测试的预测有效性 二十年来影响的连续性。拟议作品的第二个推力 将检查与OPP的常规大麻使用有关的参数 后代，对认知表现的这种使用的评估和 长时间停止常规使用后可能的影响。 我们通过自我报告和尿液分析确定了约30 opps的百分比16 1/2至19岁的受试者正在使用大麻 至少每周一次，并且已经这样做了一年或更长时间。大约 过去，这个年龄段的20％在过去的程度上使用了大麻 戒烟至少六个月。在过去和现在的用户中超过一半 平均每周至少5个关节。通过在主题之间和主题之间使用 比较我们将解决这样的问题：是否有预售 非用户和未来用户之间的认知差异；是否有一个 对认知表现的影响，超出了急性中毒 阶段虽然中枢神经系统中可能存在药物残留物或井 在清除了这种残留物之后。我们有独特的机会 在同一主题中首次检查认知表现 在使用常规大麻使用之前，在此期间和之后 长时间停止。 OPPS样本的低风险性质，大量 背景信息以及纵向神经心理学数据 婴儿期的年轻允许检查大麻使用的病因 以及以许多人确定的方式对认知表现的后果 研究人员是务实的最佳方案。