Prenatal Cannabis & Cigarette Exposure - Outcome

产前大麻

• 批准号: 6466438
• 负责人: PETER A FRIED
• 金额: $ 21.87万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6466438
• 关键词: alcoholism /alcohol abuse; attention; behavioral /social science research tag; clinical research; cognition; disease /disorder proneness /risk; drug /alcohol abstinence; embryo /fetus toxicology; human subject; longitudinal human study; marijuana abuse; memory; neuropsychological tests; peer group; performance; questionnaires; smoking cessation; tobacco abuse; urinalysis; young adult human (21-34)

DESCRIPTION (provided by applicant): Since 1978, a longitudinal study -- the Ottawa Prenatal Prospective Study (OPPS) -- has been investigating a low risk population, the effects of marihuana and cigarettes used during pregnancy. The general objectives of this competitive renewal are twofold and take advantage of the age of the OPPS subjects (20-23 years) who have been assessed since birth. We will continue to assess the young adults focusing upon the domains impacted by either prenatal marihuana or cigarettes at younger ages and examine the predictive validity of the infant and early childhood tests in terms of the continuity of effects over two decades. The second thrust of the proposed work will be to examine parameters related to regular marihuana use by the OPPS offspring, the evaluation of such use upon cognitive performance and an investigation of possible effects after prolonged cessation of regular usage. We have identified, via self-report and urinalysis, that approximately 30 percent of the OPPS 16 1/2 to 19 year old subjects are using marihuana on at least a weekly basis and have been doing so for a year or more. Approximately 20 percent in this age range have used marihuana to that extent in the past but have quit for at least six months. Among these past and present users over half averaged at least 5 joints per week. By using both within and between subject comparisons we will address such question as: whether there are predrug cognitive differences between non-users and future users; whether there is an impact upon cognitive performance that persists beyond the acute intoxication phase either while there may be a drug residue lingering in the CNS or well after such a residue has been cleared. We have the unique opportunity to examine, for the first time within the same subjects, cognitive performance before the initiation of regular marihuana use, during such use and after prolonged cessation. The low-risk nature of the OPPS sample, the vast array of background information, and the longitudinal neuropsychological data spanning infancy to young permits an examination of both the etiology of marihuana use and the consequences on cognitive performance in a manner identified by many researchers as being the pragmatically optimal protocol.

描述（由申请人提供）：自 1978 年以来，一项纵向研究—— 渥太华产前前瞻性研究 (OPPS)——一直在调查低风险 人口、怀孕期间使用大麻和香烟的影响。这 这种竞争性更新的总体目标是双重的，并利用 自此以来接受评估的 OPPS 受试者的年龄（20-23 岁） 出生。我们将继续评估专注于这些领域的年轻人 受产前大麻或年轻时吸烟的影响并检查 婴儿和幼儿测试的预测有效性 二十年来影响的连续性。拟议工作的第二个重点 将检查与 OPPS 常规使用大麻相关的参数 后代，对这种使用的认知表现和评估 调查长期停止经常使用后可能产生的影响。 通过自我报告和尿液分析，我们发现大约 30 OPPS 16 1/2 至 19 岁受试者中吸食大麻的百分比 至少每周一次，并且已经这样做了一年或更长时间。大约 这个年龄段的人中有 20% 的人过去曾吸食过这种程度的大麻，但 已戒烟至少六个月。在这些过去和现在的用户中，超过一半 平均每周至少 5 个关节。通过在主题内和主题之间使用 比较我们将解决这样的问题：是否有前药 非用户和未来用户之间的认知差异；是否有一个 对认知表现的影响在急性中毒后持续存在 中枢神经系统或井中可能存在药物残留 清除此类残留物后。我们有独特的机会 首次在同一受试者中检查认知表现 在开始常规使用大麻之前、使用期间和之后 长时间停止。 OPPS 样本的低风险性质、大量的 背景信息和纵向神经心理学数据 从婴儿期到青少年都可以检查吸食大麻的病因 以及以许多人认为的方式对认知表现的影响 研究人员认为这是实用的最佳方案。