PRENATAL CANNABIS AND CIGARETTE CONSEQUENCES

产前大麻和香烟的后果

• 批准号: 3210669
• 负责人: PETER A FRIED
• 金额: $ 14.41万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3210669
• 关键词: attention deficit disorder; behavior disorders; child mental disorders; embryo /fetus toxicology; hearing disorders; human subject; language disorders; learning disorders; longitudinal human study; marijuana abuse; memory disorders; middle childhood (6-11); neuropsychological tests; passive smoking; psychomotor disorders; questionnaires; statistics /biometry; tobacco abuse; vision disorders

Since 1978, a longitudinal study investigating the effects of marihuana and cigarettes used during pregnancy has been underway. The overall purpose of this Ottawa Prenatal Prospective Study (OPPS) is to examine the effects of these drugs on pregnancy, the neonate and the child. The general objective of this competitive renewal is to determine whether particular developmental sequelae and behavioral difficulties observed in the newborn, infant, and young child that are statistically associated, in a differential fashion, with prenatal marihuana and cigarette exposure persist in the o 1/2 to 11 year 11 month old child and whether, by an in depth neurobehavioural assessment, a greater degree of specificity of dysfunction can be identified. Additionally, because of the longitudinal nature of this OPPS, the predictive validity of the infant and early childhood tests can be examined as can the continuity of effects over age. The neurobehavioural battery will focus upon those behaviors which we have identified to be vulnerable to the drugs in question. In Particular the assessment will include an examination of language and auditory processing, aspects of reading (including visual and auditory components), visual and non-visual perception, motor tasks, memory tasks, reasoning ability, intelligence, academic readiness, impulsivity sustained attention, psychological status and behavior (as assessed by the parent, teacher and examiner). Material variables (e.g. health, nutrition, parity, education, age, other drugs, intelligence, personality) and postnatal, environmental variables (e.g. home environment, second hand smoke [using urine analysis and questionnaires], and schooling experience) will be included in multivariate statistical analysis. The OPPS is the only work to have published data on marihuana users' offspring beyond a very early childhood and is the most comprehensive longitudinal work examining school age children of cigarette smokers. The testing of children at approximately 10 years of age is particularly critical as the identification of subtle learning difficulties is most likely to manifest themselves when complex behaviors requiring focused attention and cognitive skills, normally present at this stage of development, can be examined in depth.

自1978年以来，一项纵向研究调查了大麻的影响， 怀孕期间吸烟的问题已经开始了。 整体 这项渥太华产前前瞻性研究（OPPS）的目的是检查 这些药物对妊娠、新生儿和儿童的影响。 的 本次竞争性续约的总体目标是确定 观察到特定的发育后遗症和行为困难 在新生儿，婴儿和幼儿中， 与产前大麻有关， 在0 1/2至11岁11个月的儿童中， 通过深入的神经行为评估， 可以识别功能障碍的特异性。 此外，由于 这种OPPS的纵向性质，预测有效性， 婴儿和幼儿测试可以检查，因为可以连续性 年龄的影响。 神经行为电池将集中在那些行为， 已经被确定对所述药物敏感。 特别是 评估将包括语言和听觉检查 处理，阅读方面（包括视觉和听觉 组件），视觉和非视觉感知，运动任务，记忆任务， 推理能力，智力，学术准备，冲动 持续的注意力、心理状态和行为（由 家长、老师和考官）。材料变量（如健康、 营养，平等，教育，年龄，其他药物，智力， 个性）和产后，环境变量（如家庭 环境，二手烟[使用尿液分析和问卷调查]， 和教育经验）将纳入多元统计 分析. OPPS是唯一一个公布大麻使用者数据的机构。 儿童早期的后代，是最全面的 对吸烟者的学龄儿童进行纵向研究。 对10岁左右的儿童进行测试尤其重要。 关键是识别微妙的学习困难是最重要的 当复杂的行为需要集中注意力时， 注意力和认知能力，通常出现在这个阶段， 发展，可以深入研究。