MOLECULAR AND GENETIC APPROACHES TO CHILDHOOD DISEASES

此应用程序请求支持儿童健康研究中心 (CHRC)在斯坦福大学医学院。科学使命 建议的CHRC的目的是将初级和高级教职员工聚集在一起 儿科和其他科室的教职员工 有相关利害关系的人，以方便申请 解决儿童悬而未决问题的细胞、分子和遗传学方法 健康。该项目的领导将由哈维·科恩博士提供， 儿科主任和助理医生Ann Arvin 学术事务主席。CHRC的主要目标是 支持受过临床培训的年轻研究人员的研究 为了增加他们在儿科研究基础知识的机会 儿童疾病的机制。我们的前提是这新一代 对儿科研究人员有重要贡献 儿科实践的未来。在他们的前辈的指导下 同事们，这些调查人员必须有适当的早期职业生涯 将“长椅到床边”的概念变成现实的经验 孩子们。这一目标将通过创建三个 主要研究亲和力小组，将组成免疫学计划 和移植生物学，遗传学和癌症生物学项目 和发育生物学项目。高级、中级和初级 教师将根据自己的个人情况参加这些计划 研究兴趣。每个项目的初级教员将有资格 争夺旨在帮助他们实现以下目标的新项目开发奖 基础科学研究方面的必要专业知识。第二个目标是 CHRC将创建一个儿科核心实验室。CHRC的资金将是 用于管理功能强大的交互式技术支持设施 有适当的教育计划，并购买必要的设备 常用的。该设施的设计将满足以下需求 系教职员工在职业发展的所有阶段，充当 关于新科学技术及其相关知识的教育资源 应用于生物医学研究和作为联合购买机制 并共同使用这项工作所需的非常昂贵的设备。这 对CHRC支持的请求是在历史上一个独特的时刻提出的 我们的儿科是建立在一个重大的新机构基础上的 致力于发展与儿童相关的基础研究项目 健康。已提供资源，以便征聘以下人员： 在五年内至少有十名以实验室为基础的初级教员 与CHRC的支持和新改建的广泛实验室不谋而合 空间已被分配给儿科。该大学的学术计划 儿科系与新的Lucile Salter Packard联系在一起 儿童医院，这是一种资源，使我们的环境成为 将儿科研究的进展直接转化为改善 儿童健康。

This application requests support for a Child Health Research Center (CHRC) at Stanford University School of Medicine. The scientific mission of the proposed CHRC is to bring together the junior and senior faculty of the Department of Pediatrics and faculty members from other departments who have related interests, in order to facilitate the application of cellular, molecular and genetic methods to unresolved problems in child health. Leadership of the program will be provided by Dr. Harvey Cohen, the chairman of the Department of Pediatrics, and Dr. Ann Arvin, Associate Chair for Academic Affairs. The primary objective of the CHRC is to support the research of younger investigators who have clinical training in pediatrics in order to enhance their opportunities to investigate basic mechanisms of childhood diseases. Our premise is that this new generation of pediatric investigators has an essential contribution to make to the future of pediatric practice. With the guidance of their senior colleagues, these investigators must have appropriate early career experiences to make the "bench to bedside" concept into a reality for children. This objective will be addressed through the creation of three primary research affinity groups, to consist of the Program in Immunology and Transplantation Biology, the Program in Genetics and Cancer Biology and the Program in Developmental Biology. Senior, mid-level and junior faculty will participate in these programs according to their individual research interests. Junior faculty from each program will be eligible to compete for New Project Development Awards designed to help them achieve necessary expertise in basic scientific research. The second objective of the CHRC is to create a Pediatric Core Laboratory. CHRC funds will be used to administer a functional, interactive technical support facility with appropriate educational programs and to buy essential equipment for common use. This facility will be designed to serve the needs of department faculty at all stages of career development, acting as a resource for education about new scientific technology and its applications to biomedical research and as a mechanism for joint purchase and shared use of the very costly equipment needed for this work. This request for CHRC support is being made at a unique time in the history of our Department of Pediatrics and is based on a major new institutional commitment to the growth of basic research programs related to child health. Resources have been provided that will permit recruitment of at least ten laboratory-based junior faculty during the five year period that coincides with CHRC support and extensive, newly remodelled laboratory space has been assigned to pediatrics. The academic programs of the Department of Pediatrics are associated with the new Lucile Salter Packard Children's Hospital, a resource which makes our environment ideal for the direct transfer of advancements in pediatric research to improving the health of children.