MOLECULAR AND GENETIC APPROACHES TO CHILDHOOD DISEASES

儿童疾病的分子和遗传学方法

• 批准号: 2609129
• 负责人: HARVEY J COHEN
• 金额: $ 35万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2609129
• 关键词: biomedical facility; cell sorting; computer assisted sequence analysis; developmental genetics; health science research; immunology; molecular pathology; nucleic acid chemical synthesis; nucleic acid sequence; pediatric neoplasm /cancer; pediatrics; peptide chemical synthesis; perinatal; postnatal growth disorder; protein sequence; transplantation

This application requests support for a Child Health Research Center (CHRC) at Stanford University School of Medicine. The scientific mission of the proposed CHRC is to bring together the junior and senior faculty of the Department of Pediatrics and faculty members from other departments who have related interests, in order to facilitate the application of cellular, molecular and genetic methods to unresolved problems in child health. Leadership of the program will be provided by Dr. Harvey Cohen, the chairman of the Department of Pediatrics, and Dr. Ann Arvin, Associate Chair for Academic Affairs. The primary objective of the CHRC is to support the research of younger investigators who have clinical training in pediatrics in order to enhance their opportunities to investigate basic mechanisms of childhood diseases. Our premise is that this new generation of pediatric investigators has an essential contribution to make to the future of pediatric practice. With the guidance of their senior colleagues, these investigators must have appropriate early career experiences to make the "bench to bedside" concept into a reality for children. This objective will be addressed through the creation of three primary research affinity groups, to consist of the Program in Immunology and Transplantation Biology, the Program in Genetics and Cancer Biology and the Program in Developmental Biology. Senior, mid-level and junior faculty will participate in these programs according to their individual research interests. Junior faculty from each program will be eligible to compete for New Project Development Awards designed to help them achieve necessary expertise in basic scientific research. The second objective of the CHRC is to create a Pediatric Core Laboratory. CHRC funds will be used to administer a functional, interactive technical support facility with appropriate educational programs and to buy essential equipment for common use. This facility will be designed to serve the needs of department faculty at all stages of career development, acting as a resource for education about new scientific technology and its applications to biomedical research and as a mechanism for joint purchase and shared use of the very costly equipment needed for this work. This request for CHRC support is being made at a unique time in the history of our Department of Pediatrics and is based on a major new institutional commitment to the growth of basic research programs related to child health. Resources have been provided that will permit recruitment of at least ten laboratory-based junior faculty during the five year period that coincides with CHRC support and extensive, newly remodelled laboratory space has been assigned to pediatrics. The academic programs of the Department of Pediatrics are associated with the new Lucile Salter Packard Children's Hospital, a resource which makes our environment ideal for the direct transfer of advancements in pediatric research to improving the health of children.

此应用程序请求支持儿童健康研究中心 （CHRC）在斯坦福大学医学院。 科学使命 的建议CHRC是汇集初级和高级教师， 儿科系和其他系的教员 谁有相关的利益，以方便申请 细胞、分子和遗传学方法来解决儿童未解决的问题 健康 该计划的领导将由哈维科恩博士， 儿科系主任和副主任安阿尔文博士 学术事务主席。 加拿大人权委员会的主要目标是 支持接受过临床培训的年轻研究者的研究 在儿科，以提高他们的机会，研究基本的 儿童疾病的机制。 我们的前提是， 儿科研究人员的贡献是至关重要的， 儿科实践的未来 在前辈的指导下， 同事们，这些研究人员必须有适当的早期职业生涯 使“从长凳到床边”的概念成为现实， 孩子 这一目标将通过建立三个 主要研究亲和团体，包括免疫学计划 移植生物学，遗传学和癌症生物学计划 和发育生物学项目 高级、中级和初级 教师将根据他们的个人参加这些计划 研究兴趣。 每个项目的初级教师将有资格 竞争新项目开发奖，旨在帮助他们实现 在基础科研方面的必要专门知识。 的第二个目标 CHRC将建立一个儿科核心实验室。 CHRC基金将 用于管理功能性交互式技术支持设施 提供适当的教育计划，并购买必要的设备， 常用。 这一设施的设计将满足以下方面的需要： 系教师在职业发展的各个阶段，作为一个 新科技教育资源及其 应用于生物医学研究，并作为联合采购机制 并共同使用这项工作所需的昂贵设备。 这 对CHRC支持的请求是在历史上一个独特的时刻提出的， 我们的儿科部门，是基于一个主要的新机构 致力于发展与儿童有关的基础研究项目 健康 已提供资源， 在五年内至少有十名实验室初级教师， 与CHRC的支持和广泛的，新改建的实验室相吻合 空间已分配给儿科。 该学院的学术课程 儿科系与新的露西尔索尔特帕卡德 儿童医院，一个资源，使我们的环境理想的， 直接转移儿科研究的进展，以改善 儿童的健康。