MOLECULAR AND GENETIC APPROACHES TO CHILDHOOD DISEASES

儿童疾病的分子和遗传学方法

• 批准号: 6125644
• 负责人: HARVEY J COHEN
• 金额: $ 35万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6125644
• 关键词: biomedical facility; cell sorting; computer assisted sequence analysis; developmental genetics; health science research; immunology; molecular pathology; nucleic acid chemical synthesis; nucleic acid sequence; pediatric neoplasm /cancer; pediatrics; peptide chemical synthesis; perinatal; postnatal growth disorder; protein sequence; transplantation

This application requests support for a Child Health Research Center (CHRC) at Stanford University School of Medicine. The scientific mission of the proposed CHRC is to bring together the junior and senior faculty of the Department of Pediatrics and faculty members from other departments who have related interests, in order to facilitate the application of cellular, molecular and genetic methods to unresolved problems in child health. Leadership of the program will be provided by Dr. Harvey Cohen, the chairman of the Department of Pediatrics, and Dr. Ann Arvin, Associate Chair for Academic Affairs. The primary objective of the CHRC is to support the research of younger investigators who have clinical training in pediatrics in order to enhance their opportunities to investigate basic mechanisms of childhood diseases. Our premise is that this new generation of pediatric investigators has an essential contribution to make to the future of pediatric practice. With the guidance of their senior colleagues, these investigators must have appropriate early career experiences to make the "bench to bedside" concept into a reality for children. This objective will be addressed through the creation of three primary research affinity groups, to consist of the Program in Immunology and Transplantation Biology, the Program in Genetics and Cancer Biology and the Program in Developmental Biology. Senior, mid-level and junior faculty will participate in these programs according to their individual research interests. Junior faculty from each program will be eligible to compete for New Project Development Awards designed to help them achieve necessary expertise in basic scientific research. The second objective of the CHRC is to create a Pediatric Core Laboratory. CHRC funds will be used to administer a functional, interactive technical support facility with appropriate educational programs and to buy essential equipment for common use. This facility will be designed to serve the needs of department faculty at all stages of career development, acting as a resource for education about new scientific technology and its applications to biomedical research and as a mechanism for joint purchase and shared use of the very costly equipment needed for this work. This request for CHRC support is being made at a unique time in the history of our Department of Pediatrics and is based on a major new institutional commitment to the growth of basic research programs related to child health. Resources have been provided that will permit recruitment of at least ten laboratory-based junior faculty during the five year period that coincides with CHRC support and extensive, newly remodelled laboratory space has been assigned to pediatrics. The academic programs of the Department of Pediatrics are associated with the new Lucile Salter Packard Children's Hospital, a resource which makes our environment ideal for the direct transfer of advancements in pediatric research to improving the health of children.

此申请请求对儿童健康研究中心的支持 （CHRC）在斯坦福大学医学院。 科学使命 拟议的 CHRC 的目的是将初级和高级教师聚集在一起 儿科及其他科室的教职人员 有相关利益的人，以方便申请 细胞、分子和遗传方法来解决儿童未解决的问题 健康。 该计划的领导将由 Harvey Cohen 博士负责， 儿科主任和副主任 Ann Arvin 博士 学术事务主席。 CHRC 的主要目标是 支持接受过临床培训的年轻研究人员的研究 儿科，以增加他们研究基础知识的机会 儿童疾病的机制。 我们的前提是新一代 的儿科研究人员可以做出重要贡献 儿科实践的未来。 在前辈的指导下 同事们，这些调查员必须有适当的早期职业生涯 经验将“从工作台到床边”的概念变为现实 孩子们。 这一目标将通过创建三个 主要研究亲和小组，由免疫学项目组成 和移植生物学，遗传学和癌症生物学项目 和发育生物学项目。 高级、中级、初级 教师将根据个人情况参加这些项目 研究兴趣。 每个项目的初级教师将有资格 争夺旨在帮助他们实现目标的新项目开发奖 基础科学研究所需的专业知识。 第二个目标是 CHRC 将创建一个儿科核心实验室。 CHRC 资金将 用于管理功能性、交互式技术支持设施 制定适当的教育计划并购买必要的设备 共同使用。 该设施的设计目的是为了满足 部门教师在职业发展的各个阶段，充当 新科学技术及其相关教育资源 在生物医学研究中的应用以及作为联合购买的机制 并共享使用这项工作所需的非常昂贵的设备。 这 对 CHRC 支持的请求是在历史上的一个独特时刻提出的 我们的儿科系以一个重要的新机构为基础 致力于发展与儿童相关的基础研究项目 健康。 已提供资源，允许招聘 五年内至少有十名实验室初级教师 与 CHRC 的支持和新改建的广泛实验室相吻合 空间已分配给儿科。 该学院的学术课程 儿科与新 Lucile Salter Packard 相关 儿童医院是一种资源，使我们的环境成为儿童的理想选择 直接将儿科研究的进展转化为改善 儿童的健康。