THE DEVELOPMENT OF ANLAYTICAL PROGRAMS FOR GENETIC EPIDEMIOLOGICAL STUDIES

使用DNA标记物检测颅面和 口腔疾病利用各种各样的统计技术。 我们 正在制定一项计划，以更好地整合这些软件工具。 由于这些程序是在其他地方使用各种 计算机语言和输入，将它们与我们的间隔整合在一起， 数据库将简化分析过程。 这些方案包括： 1)MENDEL，以计算对数增加并估计 疾病和遗传DNA标记基因座， 2)影响同胞配对法 3)患病家系标记法 4)CRI-MAP确定多点标记物 5)HETERGEN -检测可能的基因座的连锁 异质性和计算混合比值LOD评分 6)SIMLINK -估计检测的概率或功效 一组家族谱系的连锁。 这个程序模拟 家系中性状和标记基因座的共分离， 客观功效计算，以确定是否收集 家庭足以证明联系。

Gene mapping studies using DNA markers to detect craniofacial and oral diseases utilize a wide variety of statistical techniques. We are developing a scheme to better integrate these software tools. Since these programs were written elsewhere using a variety of computer languages and input for integrating them with our interval database will streamline the analysis process. The programs include: 1) MENDEL, to calculate log adds and estimate linkage between disease and genetic DNA marker loci, 2) affected sibling pair method 3) affected pedigree marker method 4) CRI-MAP to determine multi-point marker 5) HETERGEN - to test for linkage allowing for possible locus heterogeneity and calculating admixture odds LOD scores 6) SIMLINK - to estimate the probability or power of detecting linkage for a set of family pedigrees. This program simulates cosegregation of trait and marker loci in pedigrees resulting in an objective power calculation to determine if the collection of families is sufficient to demonstrate linkage.