THE DEVELOPMENT OF ANLAYTICAL PROGRAMS FOR GENETIC EPIDEMIOLOGICAL STUDIES

遗传流行病学研究分析程序的开发

• 批准号: 2572409
• 负责人: S R DIEHL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2572409
• 关键词: computer program /software; computer system design /evaluation; craniofacial; epidemiology; family genetics; genetic disorder; genetic mapping; genetic markers; human data; linkage mapping; oral pharyngeal disorder; statistics /biometry

Gene mapping studies using DNA markers to detect craniofacial and oral diseases utilize a wide variety of statistical techniques. We are developing a scheme to better integrate these software tools. Since these programs were written elsewhere using a variety of computer languages and input for integrating them with our interval database will streamline the analysis process. The programs include: 1) MENDEL, to calculate log adds and estimate linkage between disease and genetic DNA marker loci, 2) affected sibling pair method 3) affected pedigree marker method 4) CRI-MAP to determine multi-point marker 5) HETERGEN - to test for linkage allowing for possible locus heterogeneity and calculating admixture odds LOD scores 6) SIMLINK - to estimate the probability or power of detecting linkage for a set of family pedigrees. This program simulates cosegregation of trait and marker loci in pedigrees resulting in an objective power calculation to determine if the collection of families is sufficient to demonstrate linkage.

用DNA标记检测颅面和颌面部肿瘤的基因作图研究 口腔疾病利用了各种各样的统计技术。我们 正在制定一项计划，以更好地整合这些软件工具。 由于这些程序是在其他地方使用各种 计算机语言和输入，用于将它们与我们的音程相结合 数据库将简化分析过程。这些计划包括： 1)Mendel，计算对数相加和估计之间的联系 疾病和遗传DNA标记基因座， 2)影响同胞配对法 3)受影响的系谱标记方法 4)CRI-MAP确定多点标记 5)HETERGEN-测试允许可能的基因座的连锁 异质性与混合优势LOD得分的计算 6)SIMLINK-估计检测的概率或能力 一组家系的连锁性。该程序模拟 家系中性状和标记基因座的共分离导致了 客观功率计算来确定是否收集 家庭足以证明相互之间的联系。