DEVELOPMENT OF DATABASE FOR GENETIC EPIDEMIOLOGICAL STUDIES

MEDIB已经开始开发、实施和记录一个全面的 实验室数据管理系统。该系统将用于 用于基因图谱的临床、家系和基因数据的管理 学习。数据库格式应用于多个数据库(其中 其中，青少年牙周炎、唇腭裂和Karagener 综合症)。数据库和程序将在第4天实施 Mackintosh计算机上的维度(4D)。乔治·蒂勒先生，4D注册 开发商，正在与MEDIB员工合作开发适当的 程序和文档。完成的系统将集成和 管理临床信息、家族史和标记等位基因分型 并为1)广泛的错误检查提供交互过程2) 生成适合输入到各种链接的格式化文件 分析程序，以及3)提供引物清单和用于跟踪DNA 样本和由它们产生的细胞系。 未来的影响将包括开发1)检查基因的程序 不兼容性和2)舍入和禁止等位基因大小，以获得更直接的 输入到数据库中。

MEDIB has begun developing, implementing and documenting a comprehensive laboratory data management system. This system will be used for the management of clinical, pedigree and genotype data for gene mapping studies. The database format shall be used for multiple databases (among them, juvenile periodontitis, cleft lip and palate and Kartagener Syndrome). The databases and programs will be implemented in 4th Dimension (4D) on Mackintosh computers. Mr. George Tiller, 4D Register Developer, is cooperating with MEDIB staff to develop appropriate procedures and documentation. The completed system will integrate and manage clinical information, family histories, and marker-allele typing as well as provide interactive procedures for 1) extensive error checking 2) generation of formatted files suitable for input to various linkage analysis programs, and 3) provide primer inventories and for tracking DNA samples and the cell lines produced from them. Future effects will include developing procedures for 1) checking genetic incompatibilities and 2) rounding and banning allele sizes for more direct input into the database.