MAPPING OF CLEFT LIP AND PALATE IN MICE

小鼠唇裂和腭裂的绘图

• 批准号: 5201875
• 负责人: S R DIEHL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201875
• 关键词: cleft lip; cleft palate; gene expression; genetic mapping; genetic markers; human subject; laboratory mouse

The human/mouse homology map provides an excellent tool to identify candidate genes involved in human disease. Studies have been initiated using several newly identified loci in man that are candidates for involvement in facial clefting. In collaboration with Dr. Erikson, we have used markers for homologous positions in the mouse to search for QTLs affecting facial clefting. The search identified a region of mouse chromosome 3 homologous to human 1q21 as increasing liability to sporadic CL(P) when the A/J strain allele is present. This effect might be expected since the A/J strain has much higher incidence of sporadic CL9P) than does the C57B16J strain, the other progenitor strain of the RI lines.

人/小鼠同源图谱提供了一个很好的工具， 与人类疾病有关的候选基因 研究已经开始， 使用几个新发现的人类基因座， 参与面部裂缝 与埃里克森博士合作，我们 已经使用小鼠中同源位置的标记来搜索QTL 造成面部裂缝 搜索确定了一个区域的鼠标 与人类1 q21同源的3号染色体增加了对散发性 CL（P）当存在A/J株等位基因时。 其作用机制可能 由于A/J株散发性CL 9 P的发病率高得多，因此预期 C57 B16 J菌株，RI系的另一个祖先菌株。