GENETIC EPIDEMIOLOGICAL STUDIES OF ORAL CANCER IN TAIWAN

台湾口腔癌的遗传流行病学研究

• 批准号: 6161875
• 负责人: S R DIEHL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161875
• 关键词: Taiwan; alcoholic beverage consumption; blood chemistry; cancer risk; case history; clinical research; cytochrome P450; family genetics; genetic polymorphism; histopathology; human subject; interview; linkage disequilibriums; linkage mapping; mouth neoplasms; mouthwash; neoplasm /cancer epidemiology; neoplasm /cancer genetics; questionnaires; smoking

Three inter-related studies of oral cancer genetic epidemiology were conducted in Taiwan during the past year. These studies were aimed at determining the basic causes of this disease. First, we have studied a case-control sample and found an association between genetic variation at the Cytochrome P450 gene 1A1 which interacts with exposure to risk factors such as smoking and drinking. Second, we have obtained questionnaire data regarding the family history of this disease and correlation with risk factors. Third, we have identified 100 families suitable for sampling for gene mapping studies based on linkage and/or linkage disequilibrium approaches and this sampling of blood, oral rinse, tumor tissues and questionnaire data has commenced.

三项相互关联的口腔癌遗传流行病学研究， 去年在台湾举办的。 这些研究旨在 确定这种疾病的基本原因。 首先，我们研究了 病例对照样本，并发现遗传变异之间的关联， 与暴露于危险因素相互作用的细胞色素P450基因1A 1 比如吸烟和喝酒。 第二，我们获得了问卷调查数据 关于这种疾病的家族史和与风险的相关性， 因素 第三，我们确定了100个适合抽样的家庭， 基于连锁和/或连锁不平衡的基因定位研究 这种方法和血液，口腔冲洗，肿瘤组织和 问卷调查数据已经开始。