MAPPING OF CLEFT LIP AND PALATE IN MICE

人/鼠的同源图谱提供了一个很好的工具来识别 涉及人类疾病的候选基因。研究表明， 在人类中使用几个新发现的基因座启动 参与面部裂隙手术的候选人。与 埃里克森博士，我们已经用标记标记了 鼠标搜索影响面部裂隙的QTL。搜索 鉴定出小鼠3号染色体与人类1q21同源的区域为 当A/J株等位基因为 现在时。这种影响可能是意料之中的，因为A/J菌株有很多 散发性CL9P的发病率)高于C57B16J菌株， RI系的其他祖先品系。

The human/mouse homology map provides an excellent tool to identify candidate genes involved in human disease. Studies have been initiated using several newly identified loci in man that are candidates for involvement in facial clefting. In collaboration with Dr. Erikson, we have used markers for homologous positions in the mouse to search for QTLs affecting facial clefting. The search identified a region of mouse chromosome 3 homologous to human 1q21 as increasing liability to sporadic CL(P) when the A/J strain allele is present. This effect might be expected since the A/J strain has much higher incidence of sporadic CL9P) than does the C57B16J strain, the other progenitor strain of the RI lines.