Structural Biology Core

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ABSTRACT An integrated Structural Biology Core will be established to enable the Research Projects’ scientists employing state-of-the-art tools for structural determinations from RNA, protein to virus and virus infected cells. This Core is made up of three Subcores including protein production, x-ray crystallography and scattering, and cryogenic electron microscopy and tomography. All the imaging and diffraction instruments are located at the SLAC National Accelerator Laboratory campus of Stanford University while the protein production is embedded in the ChEM-H Institute on the main campus. All of the facilities are maintained by experienced staff at SLAC under the supervision of Drs. Chiu, Hedman, and Hodgson. The Core will be staffed by specialists to assist and train the AViDD Center’s scientists in performing the structure characterizations to enable the design of novel and effective antivirals against SARS-CoV-2 and other RNA viruses of pandemic potential.