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Structural Biology Core

结构生物学核心

基本信息

批准号：
10514266
负责人：
Wah Chiu
金额：
$ 388万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-16 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10514266
关键词：
2019-nCoV Antiviral Agents Binding Proteins Biochemical Cells Complex Computer software Cryoelectron Microscopy Crystallization Crystallography Data Data Analyses Data Collection Development Devices Drug Targeting Electron Microscope Electron Microscopy Electron Microscopy Facility Faculty Fluorescence Funding Image Informatics Infrastructure Institutes Ions Joints Knowledge Laboratories Membrane Membrane Proteins Methodology Methods Microscopy Modeling Molecular Biology Molecular Structure National Institute of General Medical Sciences Outpatients Pathologic Pharmacotherapy Preparation Production Proteins RNA RNA Viruses Research Personnel Research Project Grants Resolution Resources Robotics Roentgen Rays Sampling Scientist Specialist Structure Subcellular structure Supervision Synchrotrons System Temperature Time Training Universities Validation Viral Viral Proteins Virus X-Ray Crystallography base cellular imaging computerized data processing cryogenics data management data reduction design electron tomography experience high throughput screening image processing instrument instrumentation macromolecule nanometer novel pandemic disease particle protein expression rational design reconstruction screening structural biology structural genomics synchrotron radiation three-dimensional visualization tomography tool viral RNA

项目摘要

ABSTRACT An integrated Structural Biology Core will be established to enable the Research Projects’ scientists employing state-of-the-art tools for structural determinations from RNA, protein to virus and virus infected cells. This Core is made up of three Subcores including protein production, x-ray crystallography and scattering, and cryogenic electron microscopy and tomography. All the imaging and diffraction instruments are located at the SLAC National Accelerator Laboratory campus of Stanford University while the protein production is embedded in the ChEM-H Institute on the main campus. All of the facilities are maintained by experienced staff at SLAC under the supervision of Drs. Chiu, Hedman, and Hodgson. The Core will be staffed by specialists to assist and train the AViDD Center’s scientists in performing the structure characterizations to enable the design of novel and effective antivirals against SARS-CoV-2 and other RNA viruses of pandemic potential.

摘要将建立一个综合的结构生物学核心，使研究项目的科学家采用最先进的工具进行从RNA、蛋白质到病毒和病毒感染细胞的结构测定。该核心由三个子核心组成，包括蛋白质生产，X射线晶体学和散射，低温电子显微镜和断层扫描。所有的成像和衍射仪器都位于 SLAC国家加速器实验室校园的斯坦福大学，而蛋白质生产嵌入在主校区的化学-H研究所。所有设施均由SLAC经验丰富的员工维护在赵海德曼和霍奇森医生的监督下核心将配备专家提供协助并培训AViDD中心的科学家进行结构表征，使设计针对SARS-CoV-2和其他具有大流行潜力的RNA病毒的新型有效抗病毒药物。