Volumetric imaging facility: observing the cell in its native environment

体积成像设施：观察细胞在其原生环境中的情况

• 批准号: LE190100130
• 负责人: Prof Dayong Jin
• 金额: $ 98.69万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE190100130
• 关键词: Volumetric; imaging; facility; observing; cell

This project aims to establish a National volumetric imaging platform for functional imaging of multi-cellular networks. The facility will integrate new super-resolution imaging modalities, a library of near infrared molecular probes, and microfluidics technologies to enable real-time observation of 3D engineered organoids. This new optical imaging platform will allow users to watch the inner workings of cells through deep tissue with high speed, ultra-sensitivity, and in four dimensions, rather than today's typical two dimensions. Focus areas include the emerging development and study of mini versions of organs and hard-to-culture microbial matter. This facility is expected to provide benefits across the fields of physics, optics, chemical and material sciences, photonics, biotechnology and engineering.

该项目旨在建立一个国家体积成像平台，用于多细胞网络的功能成像。该设施将整合新的超分辨率成像模式，近红外分子探针库和微流体技术，以实现对3D工程类器官的实时观察。这种新的光学成像平台将允许用户通过深层组织以高速，超灵敏度和四维方式观察细胞的内部运作，而不是今天典型的二维。重点领域包括器官和难以培养的微生物物质的迷你版本的新兴发展和研究。该设施预计将在物理学、光学、化学和材料科学、光子学、生物技术和工程学领域提供益处。