IMPROVED, HEAD VOLUME PHASED ARRAY FOR NMR

用于 NMR 的改进头体积相控阵

• 批准号: 2537543
• 负责人: RAVI SRINIVASAN
• 金额: $ 10万
• 依托单位: ADVANCED IMAGING RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-06 至 1999-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2537543
• 关键词: biomedical equipment development; brain imaging /visualization /scanning; human subject; image enhancement; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; phantom model

In Phase I, a novel volume RF coil array with a further 40 percent improvement in S/N for high resolution brain imaging will be developed at 1.5T. Phantom measurements and volunteer evaluations will be performed to evaluate the S/N, uniformity, coverage, claustrophobia, etc. Phase II will involve optimizing the coil design, followed by extensive phantom and volunteer evaluations to achieve a high image quality over the brain. This design will be extended to 1.0 and 0.5T field strengths, validated and clinically verified prior to productization. Submissions to the FDA and ETL for obtaining regulatory and compliance approvals will be made prior to the Phase II completion. Potential research and clinical uses include the broad-based functional, structural and vascular examinations of patients with neuropsychiatric diseases, stroke and cancer. All this will translate into improved image quality, enhanced diagnostic accuracy in reduced scan times, decreasing patient discomfort while increasing throughput in a MR scanner. This we believe will be of substantial benefit to mankind and the US economy. A further 2 increase in S/N is a significant improvement and will set a new INDUSTRY STANDARD for RF coils in the entire MRI industry. PROPOSED COMMERCIAL APPLICATION Clinical applications include non-ionizing brain imaging when compared to ionizing radiation techniques such as PET, SPECT. This project will provide a significant improvement to the MRI RF coil technology including sequence and technique optimizations. If clinical value is demonstrated, MR systems based on this technology will find widespread applications in the areas of neuropsychiatric and neurodegenerative diseases, neurology, stroke and trauma, and cancer.

在第一阶段，新型体积射频线圈阵列进一步增加了 40% 将开发高分辨率脑成像信噪比的改进 1.5T。 体模测量和志愿者评估将 进行评估信噪比、均匀性、覆盖范围、幽闭恐惧症、 ETC。 第二阶段将涉及优化线圈设计，然后进行广泛的研究 模型和志愿者评估以实现高图像质量 大脑。 此设计将扩展到1.0和0.5T领域 在产品化之前经过验证和临床验证的优势。 向 FDA 和 ETL 提交申请以获得监管和合规性 批准将在第二阶段完成之前进行。 潜在的研究和临床用途包括广泛的功能、 神经精神疾病患者的结构和血管检查 疾病、中风和癌症。 所有这一切都将转化为改进 图像质量，在减少扫描时间的情况下提高诊断准确性， 减少患者不适，同时提高 MR 的吞吐量 扫描器。 我们相信这将为人类带来巨大的利益 美国经济。 信噪比进一步增加 2 是显着的 改进并将为射频线圈制定新的行业标准 整个 MRI 行业。 拟议的商业应用 临床应用包括比较非电离脑成像 电离辐射技术，如 PET、SPECT。该项目将 显着改进 MRI 射频线圈技术 包括序列和技术优化。如果临床价值是 事实证明，基于该技术的 MR 系统将得到广泛应用 在神经精神病学和神经退行性疾病领域的应用 疾病、神经病学、中风和创伤以及癌症。