DUAL-TUNED PROBE FOR MRI/MRS OF THE HUMAN BRAIN

用于人脑 MRI/MRS 的双调谐探头

• 批准号: 6140908
• 负责人: RAVI SRINIVASAN
• 金额: $ 49.71万
• 依托单位: ADVANCED IMAGING RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6140908
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; electromagnetic radiation; human subject; image enhancement; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; phantom model; radionuclides

In Phase I, a hybrid quadrature, dual-tuned (31P-1H) probe with nearly identical field-of-view, ideal for 31H decoupled 31P spectroscopy of the entire adult bran was prototyped at 1.5T. Phantom tests and volunteer evaluations showed improved performance and extended coverage at the low gamma nucleus (31P) over the previous design. Phase II will involve prototype developments based on the new design, followed by coil comparisons and extensive phantom/volunteer evaluations at both the NMR frequencies (31P, 1H). Based on the success of the adult coil design, custom coils for imaging the pediatric brain and the adult forearm muscle will be prototyped at 1.5T. Our coil design will be upscaled in frequency to operate as a 23Na-1H head coil at 4.0T. Research on dual-tuned quadrature surface coil designs will be performed at 4.0T. Based on the success at 1.5 and 4.0T, 3.0T coils will be developed. A goal of this research is to improve image quality and spectroscopic representation of the x-nucleus over the brain in one patient setting, which will aid in the clinical diagnosis. This we believe will be of a substantial benefit to mankind. PROPOSED COMMERCIAL APPLICATION: Research and clinical applications include non-ionizing brain imaging when compared to ionizing radiation techniques such as PET, SPECT, etc. This project will provide a significant improvement to the NMR RF coil technology including sequence and technique optimizations. if clinical value is demonstrated NMR systems based on this technology will find widespread applications in the areas of stroke/epilepsy mitochondrial cytopathies cancer AIDS multiple sclerosis and neurodegenerative brain diseases.

在第一阶段，混合正交，双调谐（31 P-1H）探头几乎相同的视野，理想的31 H去耦31 P光谱的整个成年麸皮原型在1.5 T。体模测试和志愿者评价显示，与以前的设计相比，低伽马核（31 P）的性能有所改善，覆盖范围有所扩大。第二阶段将涉及基于新设计的原型开发，随后是线圈比较和两种NMR频率（31 P，1H）下的广泛体模/志愿者评价。基于成人线圈设计的成功，将在1.5T下制作用于儿科大脑和成人前臂肌肉成像的定制线圈原型。我们的线圈设计将在频率上升级，以在4.0T下作为23 Na-1H头部线圈运行。双调谐正交表面线圈设计的研究将在4.0T进行。基于1.5和4.0T的成功，将开发3.0T线圈。本研究的目标是提高图像质量和光谱表示的x-核在一个病人的大脑设置，这将有助于临床诊断。我们认为这将给人类带来重大利益。拟定商业应用：研究和临床应用包括与电离辐射技术（如PET、SPECT等）相比的非电离脑成像。该项目将对NMR RF线圈技术（包括序列和技术优化）进行重大改进。如果临床价值得到证实，基于该技术的NMR系统将在中风/癫痫、线粒体细胞病变、癌症、艾滋病、多发性硬化症和神经退行性脑疾病领域得到广泛应用。