QUADRATURE, RF COIL ARRAYS FOR MUSCULOSKELETAL MRI

用于肌肉骨骼 MRI 的正交射频线圈阵列

• 批准号: 6406164
• 负责人: RAVI SRINIVASAN
• 金额: $ 60.61万
• 依托单位: ADVANCED IMAGING RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6406164
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biophysics; clinical biomedical equipment; clinical research; computer data analysis; computer program /software; computer system design /evaluation; diagnosis quality /standard; electrical property; human subject; magnetic field; magnetic resonance imaging; mathematical model; mathematics; model design /development; musculoskeletal imaging /visualization /scanning; musculoskeletal system; nuclear magnetic resonance spectroscopy; orthopedics; phantom model; radiowave radiation

DESCRIPTION (Provided by Applicant): In Phase I, a RF coil array for high-resolution knee imaging was developed at 1.5T. Phantom tests and volunteer evaluations showed improved signal-to-noise of 24-28 percent over the industry standard. Phase II will involve optimizing the RF coil arrays based on a "new design," followed by extensive phantom and volunteer evaluations to achieve high signal-to-noise over the knee, foot and wrist joints of adults. A major technical focus is to improve the S/N of a NMR experiment by a factor of sqrt (2) over the industry standards. Potential clinical and research uses are to obtain reliable, reproducible high-resolution images needed to enhance diagnostic accuracy in possibly reduced scan times, reducing patient discomfort while increasing throughput in a MR scanner. This we believe will be of a substantial benefit to mankind. PROPOSED COMMERCIAL APPLICATION: Clinical applications include non-ionizing, non-invasive and a cost effective approach toward diagnosis of musculoskeletal diseases of the knee, foot and wrist when compared to the invasive arthrography. This project will provide improvements to MR phased array coil technology, including sequences and technique optimizations. If clinical value is demonstrated, MR systems based technology will find widespread applications in imaging the human musculosketal system.

描述（由申请人提供）：在第一阶段，射频线圈阵列用于 高分辨率膝盖成像是在 1.5T 下开发的。幻影测试和志愿者 评估显示信噪比比业界提高了 24-28% 标准。 第二阶段将涉及基于“新设计”优化射频线圈阵列， 随后进行广泛的模型和志愿者评估，以实现高 成人膝关节、足关节和腕关节的信噪比。 主要技术重点是将 NMR 实验的信噪比提高一倍 sqrt (2) 超过行业标准。潜在的临床和研究用途 是为了获得增强所需的可靠、可重复的高分辨率图像 诊断准确性可能会减少扫描时间，从而减少患者的不适 同时提高 MR 扫描仪的吞吐量。我们相信这将是 给人类带来了实实在在的利益。 拟议的商业应用： 与侵入性关节造影术相比，临床应用包括非电离、非侵入性且具有成本效益的膝关节、足部和腕部肌肉骨骼疾病诊断方法。该项目将对 MR 相控阵线圈技术进行改进，包括序列和技术优化。 如果临床价值得到证实，基于 MR 系统的技术将在人体肌肉骨骼系统成像方面得到广泛应用。