DUAL-TUNED PROBE FOR MRI/MRS OF THE HUMAN BRAIN

在第一阶段，一个具有几乎相同视场的混合正交双调谐（31P- 1h）探针在1.5T下原型化，该探针非常适合整个成人麸皮的31H去耦31P光谱。幻影测试和志愿者评估表明，与以前的设计相比，性能得到了改善，低伽马核（31P）的覆盖范围得到了扩大。第二阶段将涉及基于新设计的原型开发，随后是线圈比较和在两个核磁共振频率（31P, 1H）下广泛的模拟/志愿者评估。基于成人线圈设计的成功，用于儿童大脑和成人前臂肌肉成像的定制线圈将在1.5T的原型。我们的线圈设计将在频率上进行升级，以在4.0T下作为23Na-1H头线圈工作。研究双调谐正交表面线圈的设计将在4.0T进行。在1.5 t和4.0T线圈成功的基础上，将开发3.0T线圈。本研究的一个目标是提高图像质量和光谱表示的x核在一个病人的大脑设置，这将有助于临床诊断。我们相信这将对人类有重大的好处。拟议的商业应用：研究和临床应用包括与电离辐射技术（如PET， SPECT等）相比的非电离脑成像。该项目将为核磁共振射频线圈技术提供重大改进，包括序列和技术优化。如果临床价值得到证实，基于该技术的核磁共振系统将在中风/癫痫、线粒体细胞病变、癌症、艾滋病、多发性硬化症和神经退行性脑疾病等领域得到广泛应用。

In Phase I, a hybrid quadrature, dual-tuned (31P-1H) probe with nearly identical field-of-view, ideal for 31H decoupled 31P spectroscopy of the entire adult bran was prototyped at 1.5T. Phantom tests and volunteer evaluations showed improved performance and extended coverage at the low gamma nucleus (31P) over the previous design. Phase II will involve prototype developments based on the new design, followed by coil comparisons and extensive phantom/volunteer evaluations at both the NMR frequencies (31P, 1H). Based on the success of the adult coil design, custom coils for imaging the pediatric brain and the adult forearm muscle will be prototyped at 1.5T. Our coil design will be upscaled in frequency to operate as a 23Na-1H head coil at 4.0T. Research on dual-tuned quadrature surface coil designs will be performed at 4.0T. Based on the success at 1.5 and 4.0T, 3.0T coils will be developed. A goal of this research is to improve image quality and spectroscopic representation of the x-nucleus over the brain in one patient setting, which will aid in the clinical diagnosis. This we believe will be of a substantial benefit to mankind. PROPOSED COMMERCIAL APPLICATION: Research and clinical applications include non-ionizing brain imaging when compared to ionizing radiation techniques such as PET, SPECT, etc. This project will provide a significant improvement to the NMR RF coil technology including sequence and technique optimizations. if clinical value is demonstrated NMR systems based on this technology will find widespread applications in the areas of stroke/epilepsy mitochondrial cytopathies cancer AIDS multiple sclerosis and neurodegenerative brain diseases.