HIGH S/N, HEAD AND NECK VOLUME PHASED ARRAY FOR NMR

在第一阶段，头颈部阵列原型RF线圈能够操作 在多种（仅头部、仅颈部、头部和颈部）模式下， 在1.5T下开发。体模测量和初步志愿者扫描 将获得用于评估信噪比、均匀性、覆盖率 幽闭恐惧症等。第二阶段将涉及优化线圈设计， 然后进行广泛的体模和志愿者评估， 头部、颈部、颈椎和主动脉弓的高图像质量。 T，他的设计将扩展到1.0和0.5T场强，经确认 并在产品化之前进行临床验证。提交给FDA和 ETL将在获得监管和合规性批准之前进行 第二阶段完成。潜在的研究和临床用途包括 对大脑、颅骨、面部、颈部、颈椎进行广泛检查， 脑脊髓创伤、中风患者的血管 以及其他脑血管疾病和头颈癌。这一切 将转化为改善的图像质量，提高诊断准确性， 减少扫描时间，减少患者不适，同时增加 MR扫描仪的吞吐量。我们相信，这将是一个重大的 造福人类和美国经济。 拟定商业应用： 临床应用包括非电离、非侵入性脑、面部、 与电离辐射相比，颈部和主动脉弓成像 技术，如PET、SPECT。该项目将提供改进 MR相控阵线圈技术，包括序列和技术 优化。如果证明了临床价值，基于 该技术将在以下领域得到广泛应用： 神经变性和神经精神疾病，神经病学，中风， 血管创伤性脑和脊柱损伤，脑血管疾病， 头部和颈部的肿瘤学成像。

In Phase I, a head and neck array prototype RF coil capable of operating in the multiple (head only, neck only, head & neck) modes will be developed at l.5T. Phantom measurements and preliminary volunteer scans will be obtained to evaluate the signal-to-noise, uniformity, coverage, claustrophobia, etc. Phase II will involve optimizing the coil design, followed by extensive phantom and volunteer evaluations to achieve a high image quality over the head, neck, c-spine and the aortic arch. T,his design will be extended to 1.0 and 0.5T field strengths, validated and clinically verified prior to productization. Submissions to FDA and ETL for obtaining regulatory and compliance approvals will be made prior to the Phase II completion. Potential research and clinical uses include broad examinations of the brain, skull, face, neck, cervical spine, and blood vessels in patients with craniospinal traumatic injuries, stroke and other cerebrovascular disorders, and head and neck cancer. All this will translate into improved image quality, enhanced diagnostic accuracy in reduced scan times, decreasing patient discomfort while increasing throughput in a MR scanner. This we believe will be of substantial benefit to mankind and the US economy. PROPOSED COMMERCIAL APPLICATION: Clinical applications include non-ionizing, non-invasive brain, face, neck and aortic arch imaging when compared to ionizing radiation techniques, such as PET, SPECT. This project will provide improvements to MR phased array coil technology including sequence and technique optimizations. If clinical value is demonstrated, MR systems based on this technology will find widespread applications in the areas of neurodegenerative and neuropsychiatric diseases, neurology, stroke, vascular traumatic brain and spine injuries, cerebrovascular disease, oncologic imaging of the head and neck.