DUAL-TUNED PROBE FOR MRI/MRS OF THE HUMAN BRAIN

用于人脑 MRI/MRS 的双调谐探头

• 批准号: 2540516
• 负责人: RAVI SRINIVASAN
• 金额: $ 10万
• 依托单位: ADVANCED IMAGING RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-15 至 1999-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2540516
• 关键词: biomedical equipment development; clinical research; electromagnetic radiation; human subject; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; phantom model; radionuclides

In Phase I, a novel quadrature, dual-tuned (31P-1H) probe with nearly identical field-of-view, ideal for 1H decoupled 31P spectroscopy of the entire adult brain will be developed at 1.5T. Phantom measurements and volunteer evaluations will be performed to evaluate S/N, uniformity, coverage, claustraphobia, etc. Phase II will involve optimizing the coil design, followed by extensive phantom and volunteer evaluations to achieve improved spectral quality over the brain. This design will be extended to 3.0 and 4.0T field strengths, validated and verified by research spectroscopists. Potential research and clinical uses include the broad-based functional, structural and biochemical examinations of patients with cancer, AIDS, neuropsychiatric diseases such as schizophrenia, neurogenerative diseases such as alzheimers, stroke and epilepsy etc. All this will translate into improved image quality and spectroscopic representation of the x-nucleus over the entire brain in one patient setting, which will aid in the clinical diagnosis. This we believe will be of a substantial benefit of mankind. PROPOSED COMMERCIAL APPLICATION: Research and clinical applications include non-ionizing brain imaging when compared to ionizing radiation techniques, such as PET, SPECT, etc. This project will provide a significant improvement to the NMR RF coil technology including sequence and technique optimizations. If clinical value is demonstrated, NMR spectroscopy systems based on this technology will find widespread applications in the areas of cancer, AIDS, neuropsychiatric and neurodegenerative disease of the human brain, stroke and epilepsy etc.

在第一阶段，一种新的正交，双调谐（31 P-1H）探头， 相同的视场，非常适合1H去耦31 P光谱 在1.5T下，整个成人大脑将发育。体模测量和 将进行志愿者评价，以评价S/N，均匀性， 覆盖范围、幽闭恐惧症等。 第二阶段将涉及优化线圈设计，然后进行广泛的 体模和志愿者评估，以提高光谱质量 在大脑上。该设计将扩展到3.0和4.0T领域 强度，经研究光谱学家验证和验证。 潜在的研究和临床用途包括广泛的功能， 对癌症、艾滋病、 神经精神疾病如精神分裂症、神经变性疾病 如老年痴呆症，中风和癫痫等。所有这些都将转化为 改进X核的图像质量和光谱表示 在一个病人的整个大脑，这将有助于 临床诊断我们相信，这将是一个巨大的好处， 人类 拟定商业应用： 研究和临床应用包括非电离脑成像， 与诸如PET、SPECT等的电离辐射技术相比， 该项目将提供一个显着改善核磁共振射频线圈 技术，包括序列和技术优化。如果临床 价值得到证明，基于此技术的NMR光谱系统 将在癌症、艾滋病、 人类大脑的神经精神和神经变性疾病，中风 癫痫等。