ELECTRODERMAL DYSFUNCTIONS AND SCHIZOPHRENIA

说明书（改编自申请人的摘要）： 提出了一个研究计划，围绕四个广泛的问题，处理 临床、认知、功能和神经生理学 皮肤电活动和前脉冲抑制（PPI）的意义 惊吓眨眼反射 四个问题涉及测试预测 源自精神分裂症的脆弱性压力模型 第一个（临床）问题是紧张性皮肤电异常是否 活动指数是一种“短暂的中间状态”， 在脆弱的个体中。 第二个（认知）问题是， 在测试时，PPI可以索引自动和控制的认知过程 在研究者的“注意力-前脉冲”范式中。 第三 （功能）问题涉及PPI是否反映感觉抑制 过程，而阶段性皮肤电反应反映感觉摄入。 一 第四个（神经生理学）问题涉及大脑结构是否 异常与皮肤电和PPI异常有关， 精神分裂症 这四个问题将在随机选择的大学生中进行测试， 那些被选为“高危”的精神分裂症患者和门诊精神分裂症患者。

DESCRIPTION (adapted from applicant's abstract): The present application proposes a program of studies organized around four broad issues dealing with the clinical, cognitive, functional, and neurophysiological significance of electrodermal activity and prepulse inhibition (PPI) of the startle eyeblink reflex. The four issues involve testing predictions derived from a vulnerability stress model of schizophrenia. The first (clinical) issue is whether anomalies in tonic electrodermal activity index a "transient intermediate state" that precedes symptomatic episodes in vulnerable individuals. The second (cognitive) issue is whether PPI can index both automatic and controlled cognitive processes when tested in the investigator's "attention-to-prepulse" paradigm. The third (functional) issue concerns whether PPI reflects a sensory inhibition process, while phasic electrodermal responses reflect sensory intake. A fourth (neurophysiological) issue addresses whether brain structural abnormalities are related to electrodermal and PPI anomalies in schizophrenia. These four issues will be tested in randomly selected college students, those selected to be putatively "at-risk" and in schizophrenic outpatients.