ELECTRODERMAL DYSFUNCTIONS AND SCHIZOPHRENIA

皮肤电功能障碍和精神分裂症

• 批准号: 2430932
• 负责人: MICHAEL Edward DAWSON
• 金额: $ 12.38万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2430932
• 关键词: attention; autonomic nervous system; cognition; disease /disorder classification; disease /disorder proneness /risk; galvanic skin response; human subject; mental disorder diagnosis; neural information processing; orientation; schizophrenia; startle reaction

This competing continuation application proposes two large projects to study the skin conductance orienting response (SCOR) and startle eye-blink modification (SEM) in order to better understand attentional and affective disorders in schizophrenic outpatients and putatively psychosis-prone college students. Attentional and affective dysfunctions have long been considered central deficits in schizophrenia, but have proven complex and difficult to measure. SCOR and SEM have been hypothesized to provide non- verbal, non-voluntary indices of basic attentional and affective processes; hence they may provide unique keys to understanding these dysfunctions in schizophrenia. The overall aim of the first project, which consists of a package of five experiments, is to evaluate the contribution of automatic and controlled cognitive processing in the mediation of SCOR and SEM. All five experiments in the first project require subjects to perform a difficult visual tracking primary task while SCOR and SEM are measured to either task-irrelevant stimuli or secondary task stimuli. The rationale is that if the primary tracking task is resource-demanding, then it will engage a considerable proportion of limited processing resources, leaving only a few resources to process concurrent stimuli. Thus, it will be possible to determine the effects of varying the available processing resources on SCOR and SEM in normal college students, putatively psychosis-prone college students, recent-onset schizophrenic patients, and demographically matched normal controls. The overall aim of the second proposed project, which consists of a package of three experiments, is to develop a new paradigm to separately evaluate attentional and affective modulation of SEM. These experiments will test theoretically derived hypotheses in groups of normal college students, anhedonic college students, recent-onset schizophrenic, patients, and demographically matched normal controls. These experiments will address issues regarding the affective specificity of emotional dysfunctions and will constitute the first test of affective modulation of SEM in schizophrenic patients.

这个竞争性的延续应用程序提出了两个大型项目

项目成果

Attentional modulation of startle in psychosis-prone college students.

• DOI: 10.1111/j.1469-8986.1995.tb02955.x
• 发表时间: 1995-05
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: A. Schell;Michael E. Dawson;E. Hazlett;D. Filion

The functional relationship between visual backward masking and prepulse inhibition.

视觉后向掩蔽与前脉冲抑制之间的功能关系。

• DOI: 10.1111/j.1469-8986.2004.00153.x
• 发表时间: 2004
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Wynn,JonathanK;Dawson,MichaelE;Schell,AnneM
• 通讯作者: Schell,AnneM

Automatic and controlled attentional processes in startle eyeblink modification: effects of habituation of the prepulse.

• DOI: 10.1111/1469-8986.3740409
• 发表时间: 2000-07
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: A. Schell;J. Wynn;M. Dawson;N. Sinaii;C. B. Niebala

Probing the orienting response with startle modification and secondary reaction time.

通过惊吓修正和次级反应时间探索定向反应。

• DOI: 10.1111/j.1469-8986.1994.tb01026.x
• 发表时间: 1994
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Filion,DL;Dawson,ME;Schell,AM
• 通讯作者: Schell,AM

Electrodermal predictors of functional outcome and negative symptoms in schizophrenia.

精神分裂症功能结果和阴性症状的皮肤电预测因子。

• DOI: 10.1111/j.1469-8986.2005.00300.x
• 发表时间: 2005
• 期刊: Psychophysiology.
• 作者: Schell,AnneM;Dawson,MichaelE;Rissling,Anthony;Ventura,Joseph;Subotnik,KennethL;Gitlin,MichaelJ;Nuechterlein,KeithH
• 通讯作者: Nuechterlein,KeithH