PSYCHOPHYSIOLOGY OF SCHIZOPHRENIA

精神分裂症的心理生理学

• 批准号: 3070371
• 负责人: MICHAEL Edward DAWSON
• 金额: $ 9.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3070371
• 关键词: attention; chronic disease /disorder; cognition disorders; electromyography; haloperidol; human subject; longitudinal human study; mental disorder diagnosis; mood disorders; neuropsychological tests; psychophysiology; schizophrenia; startle reaction

This application is a request for an ADAMHA Research Scientist Development Award, Level II. The overall aim is to provide time for the PI to engage in a multi-site systematic program of research on attentional and affective dysfunctions in schizophrenia. Attentional and affective dysfunctions have long been considered central deficits in schizophrenia, but have proven complex and difficult to measure. The startle eye-blink modification paradigm is of considerable interest because it promises to be a unique key to understanding these complex dysfunctions. The startle eye-blink paradigm involves the modification of the magnitude of the startle reflex by the presentation of a non-startling stimulus (prepulse) prior to the startle stimulus. In normal subjects, the size of the effect varies reliably with attention to the prepulse and affective properties of the prepulse. Therefore, depending upon the stimulus conditions, measures of startle eye-blink modification can provide non-verbal, non-voluntary indices of basic attentional and affective processes. Three projects are proposed in order to better understand the relationship of impaired startle eye-blink modification to attentional and affective dysfunctions in schizophrenia. The first project aims to test the state versus trait characteristics of startle eye-blink modification, and its attentional modulation, in a longitudinal study of recent-onset schizophrenic outpatients. The second project aims to test whether changes in startle eye-blink modification, and its attentional modulation, are part of early signs of psychotic exacerbation in a repeated-measures study of chronic schizophrenic patients. The third project aims to develop a new startle eye-blink modification paradigm to independently evaluate attentional and affective modulation of the startle reflex, first with college students and later with schizophrenic patients. In addition to these research projects, additional training in clinical science and neuroscience is outlined for the PI.

本申请是对ADAMHA研究科学家的要求 发展奖，二级。 总的目标是提供时间， 主要研究者从事多地点系统研究计划， 注意力和情感功能障碍。 注意力和 长期以来，情感功能障碍被认为是 精神分裂症，但已被证明是复杂和难以衡量的。 的 令人震惊的眨眼修改范例引起了相当大的兴趣 因为它有望成为理解这些复杂的 功能障碍 惊吓眨眼范式涉及到幅度的修改 非惊吓刺激引起的惊吓反射 （前脉冲）在惊吓刺激之前。 在正常受试者中， 的影响可靠地变化与注意的预脉冲， 前脉冲的情感特性。 因此，根据 刺激条件下，惊吓眨眼修正的措施可以 提供非语言的、非自愿的基本注意力指数， 情感过程 为了更好地了解这三个项目， 受损惊吓眨眼修正与注意的关系 和情感功能障碍。 第一个项目旨在 测试惊吓眨眼的状态与特质特征 修改，及其注意力调制，在纵向研究， 近期发作的精神分裂症门诊病人 第二个项目旨在测试 是否改变惊吓眨眼修饰，以及其注意力 调制，是精神病急性发作的早期迹象的一部分， 慢性精神分裂症患者的重复测量研究。 第三 该项目旨在开发一种新的惊吓眨眼修正模式， 独立评估的注意力和情感调制的 惊吓反射，先是大学生，后来是精神分裂症患者 患者 除了这些研究项目外，还提供了 为PI概述了临床科学和神经科学。